| pubmed-article:20414975 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20414975 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:20414975 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:20414975 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:20414975 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:20414975 | lifeskim:mentions | umls-concept:C0178499 | lld:lifeskim |
| pubmed-article:20414975 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:20414975 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:20414975 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:20414975 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:20414975 | pubmed:dateCreated | 2010-4-22 | lld:pubmed |
| pubmed-article:20414975 | pubmed:abstractText | Basic fibroblast growth factor (bFGF), which plays an important role in tumour angiogenesis and progression, provides a potential target for cancer therapy. Here we screened a phage display heptapeptide library with bFGF and identified 11 specific bFGF-binding phage clones. Two of these clones had identical sequence and the corresponding peptide (referred to as P7) showed high homology to the immunoglobulin-like (Ig-like) domain III (D3) of high-affinity bFGF receptors, FGFR1 (IIIc) and FGFR2 (IIIc). The P7 peptide and its corresponding motif in D3 of FGFRs both carried negative charges and shared similar hydrophobic profiles. Functional analysis demonstrated that synthetic P7 peptides mediate strong inhibition of bFGF-induced cell proliferation and neovascularization. Our results demonstrate that the P7 peptide is a potent bFGF antagonist with strong antiangiogenetic activity, and might have therapeutic potential in cancer therapy. | lld:pubmed |
| pubmed-article:20414975 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20414975 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20414975 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20414975 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20414975 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20414975 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20414975 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20414975 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20414975 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20414975 | pubmed:issn | 1582-4934 | lld:pubmed |
| pubmed-article:20414975 | pubmed:author | pubmed-author:WangYiY | lld:pubmed |
| pubmed-article:20414975 | pubmed:author | pubmed-author:HuangYadongY | lld:pubmed |
| pubmed-article:20414975 | pubmed:author | pubmed-author:XiaoJianJ | lld:pubmed |
| pubmed-article:20414975 | pubmed:author | pubmed-author:XiaopingWuW | lld:pubmed |
| pubmed-article:20414975 | pubmed:author | pubmed-author:LiXiaokunX | lld:pubmed |
| pubmed-article:20414975 | pubmed:author | pubmed-author:ZengYaoyingY | lld:pubmed |
| pubmed-article:20414975 | pubmed:author | pubmed-author:SuZhijianZ | lld:pubmed |
| pubmed-article:20414975 | pubmed:author | pubmed-author:YangYongguang... | lld:pubmed |
| pubmed-article:20414975 | pubmed:author | pubmed-author:NieChangjunC | lld:pubmed |
| pubmed-article:20414975 | pubmed:author | pubmed-author:YanQiuxiaQ | lld:pubmed |
| pubmed-article:20414975 | pubmed:author | pubmed-author:HuangHuixianH | lld:pubmed |
| pubmed-article:20414975 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20414975 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:20414975 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20414975 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20414975 | pubmed:pagination | 351-6 | lld:pubmed |
| pubmed-article:20414975 | pubmed:meshHeading | pubmed-meshheading:20414975... | lld:pubmed |
| pubmed-article:20414975 | pubmed:meshHeading | pubmed-meshheading:20414975... | lld:pubmed |
| pubmed-article:20414975 | pubmed:meshHeading | pubmed-meshheading:20414975... | lld:pubmed |
| pubmed-article:20414975 | pubmed:meshHeading | pubmed-meshheading:20414975... | lld:pubmed |
| pubmed-article:20414975 | pubmed:meshHeading | pubmed-meshheading:20414975... | lld:pubmed |
| pubmed-article:20414975 | pubmed:meshHeading | pubmed-meshheading:20414975... | lld:pubmed |
| pubmed-article:20414975 | pubmed:meshHeading | pubmed-meshheading:20414975... | lld:pubmed |
| pubmed-article:20414975 | pubmed:meshHeading | pubmed-meshheading:20414975... | lld:pubmed |
| pubmed-article:20414975 | pubmed:meshHeading | pubmed-meshheading:20414975... | lld:pubmed |
| pubmed-article:20414975 | pubmed:meshHeading | pubmed-meshheading:20414975... | lld:pubmed |
| pubmed-article:20414975 | pubmed:meshHeading | pubmed-meshheading:20414975... | lld:pubmed |
| pubmed-article:20414975 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20414975 | pubmed:articleTitle | Isolation of a novel basic FGF-binding peptide with potent antiangiogenetic activity. | lld:pubmed |
| pubmed-article:20414975 | pubmed:affiliation | School of Pharmaceutical Science, Key Laboratory of Biotechnology and Pharmaceutical Engineering of Zhejiang Province, Wenzhou Medical College, Wenzhou, China | lld:pubmed |
| pubmed-article:20414975 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20414975 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
