Linked Life Data

20386757

Source:http://linkedlifedata.com/resource/pubmed/id/20386757

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-4-13
pubmed:abstractText
Lipoprotein-associated phospholipase A2 is an enzyme produced by inflammatory cells, which binds to apolipoprotein B-containing lipoproteins and degrades oxidatively modified phospholipids in low-density lipoprotein cholesterol particles, leading to formation of proinflammatory and cytotoxic products. Experimental studies suggest a role for lipoprotein-associated phospholipase A2 in the formation of advanced rupture-prone atherosclerotic lesions, and epidemiological investigations have linked it to increased cardiovascular risk. Ongoing trials are evaluating the role of novel pharmacological inhibitors of this enzyme, such as darapladib, in the management of high-risk coronary artery disease patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1916-7075
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
26 Suppl A
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27A-31A
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Lipoprotein-associated phospholipase A2: a new therapeutic target.
pubmed:affiliation
Hamilton Health Sciences and Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada. Eva.Lonn@phri.ca
pubmed:publicationType
Journal Article, Review