Source:http://linkedlifedata.com/resource/pubmed/id/20360039
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2010-10-15
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| pubmed:abstractText |
Achilles tendon pathology is a multifactorial condition for which various risk factors, including genetic factors, have been identified. Gene transfection of two members of the TGF-? family, TGF-?1 and growth/differentiation factor-5 (GDF-5), have been shown to enhance tendon repair and mechanical strength within animal Achilles tendon injury models. The objective of this study was to investigate whether two functional 5' untranslated region (UTR) single nucleotide polymorphisms (SNPs), the TGFB1 rs1800469 variant and the GDF5 rs143383 variant, were associated with ATP within an Australian ('AUS') and a South African ('SA') case-control cohort.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1462-0332
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2090-7
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| pubmed:meshHeading |
pubmed-meshheading:20360039-Achilles Tendon,
pubmed-meshheading:20360039-Adult,
pubmed-meshheading:20360039-Alleles,
pubmed-meshheading:20360039-Case-Control Studies,
pubmed-meshheading:20360039-Cohort Studies,
pubmed-meshheading:20360039-Female,
pubmed-meshheading:20360039-Genetic Association Studies,
pubmed-meshheading:20360039-Genetic Predisposition to Disease,
pubmed-meshheading:20360039-Genotype,
pubmed-meshheading:20360039-Growth Differentiation Factor 5,
pubmed-meshheading:20360039-Humans,
pubmed-meshheading:20360039-Male,
pubmed-meshheading:20360039-Middle Aged,
pubmed-meshheading:20360039-Risk Factors,
pubmed-meshheading:20360039-South Africa,
pubmed-meshheading:20360039-Tendinopathy,
pubmed-meshheading:20360039-Transforming Growth Factor beta,
pubmed-meshheading:20360039-Victoria
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology--a genetic association study.
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| pubmed:affiliation |
The Division of Health and Life Sciences, School of Health, University of Northampton, Park Campus, Northampton, UK. mposthumus@mweb.co.za
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|