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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1991-6-12
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pubmed:abstractText |
From May 1978 to September 1989 45 patients underwent 25 allogeneic and 21 autologous bone marrow transplantations (BMT) and 1 peripheral stem cell transplantation for the following indications: severe aplastic anemia (n = 4), hematological malignancies (n = 28), malignant solid tumours (n = 12) and sideroblastic anemia (n = 1). The first group of 20 patients was isolated in a conventional hospital room, while management of the aplastic phase in the second group of 25 patients was performed in a laminar air flow (LAF) unit. All patients received total decontamination. In a retrospective analysis the number of positive blood cultures during the neutropenic period was 85% in the first group, as compared with 40% in the second group, and the number of febrile episodes was 85% versus 64%, respectively. Despite the fact that the septic morbidity was lower in the LAF group, mortality during the neutropenic period (15% in group I versus 16% in group II) was unaffected and survival rate (45% in group I versus 36% in group II) did not improve. We conclude that LAF protection will only have a positive impact on survival rate if the incidence of non-infectious complications of BMT, such as organ toxicity or graft-versus-host disease, is likewise reduced.
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pubmed:language |
ger
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
0043-5325
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
82-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2028617-Adolescent,
pubmed-meshheading:2028617-Bone Marrow Transplantation,
pubmed-meshheading:2028617-Child,
pubmed-meshheading:2028617-Child, Preschool,
pubmed-meshheading:2028617-Cross Infection,
pubmed-meshheading:2028617-Environment, Controlled,
pubmed-meshheading:2028617-Female,
pubmed-meshheading:2028617-Humans,
pubmed-meshheading:2028617-Immune Tolerance,
pubmed-meshheading:2028617-Infant,
pubmed-meshheading:2028617-Male,
pubmed-meshheading:2028617-Neutropenia,
pubmed-meshheading:2028617-Opportunistic Infections,
pubmed-meshheading:2028617-Patient Isolation,
pubmed-meshheading:2028617-Postoperative Complications
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pubmed:year |
1991
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pubmed:articleTitle |
[Infections in the neutropenic phase following bone marrow transplantation: comparison of laminar airflow isolation with conventional isolation].
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pubmed:affiliation |
Universitäts-Kinderklinik, Graz.
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
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