Source:http://linkedlifedata.com/resource/pubmed/id/20230194
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2010-3-16
|
| pubmed:abstractText |
The establishment and maintenance of specialized chromatin is crucial for correct gene expression and chromosome stability in mammalian cells. Therefore, epigenetic insults are frequently observed in cancer. Several chromatin modifying enzymes have been implicated in leukemia, and are attractive candidates for the development of therapeutic agents.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1744-7631
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
405-18
|
| pubmed:meshHeading |
pubmed-meshheading:20230194-Animals,
pubmed-meshheading:20230194-Antineoplastic Agents,
pubmed-meshheading:20230194-Cell Transformation, Neoplastic,
pubmed-meshheading:20230194-Humans,
pubmed-meshheading:20230194-Leukemia,
pubmed-meshheading:20230194-Methyltransferases,
pubmed-meshheading:20230194-Oncogene Proteins, Fusion,
pubmed-meshheading:20230194-Transcription, Genetic
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development.
|
| pubmed:affiliation |
University of Connecticut, Department of Pharmaceutical Sciences, Unit 3092, 69 North Eagleville Road, Storrs, CT 06269, USA. theodore.rasmussen@uconn.edu
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|