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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5973
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pubmed:dateCreated |
2010-3-26
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pubmed:databankReference |
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pubmed:abstractText |
Extracellular matrices in diverse biological systems are cross-linked by dityrosine covalent bonds catalyzed by the peroxidase/oxidase system. We show that a peroxidase, secreted by the Anopheles gambiae midgut, and dual oxidase form a dityrosine network that decreases gut permeability to immune elicitors. This network protects the microbiota by preventing activation of epithelial immunity. It also provides a suitable environment for malaria parasites to develop within the midgut lumen without inducing nitric oxide synthase expression. Disruption of this barrier results in strong and effective pathogen-specific immune responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
26
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pubmed:volume |
327
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1644-8
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pubmed:meshHeading |
pubmed-meshheading:20223948-Animals,
pubmed-meshheading:20223948-Anopheles gambiae,
pubmed-meshheading:20223948-Anti-Bacterial Agents,
pubmed-meshheading:20223948-Bacteria,
pubmed-meshheading:20223948-Bacterial Physiological Phenomena,
pubmed-meshheading:20223948-Blood,
pubmed-meshheading:20223948-Digestive System,
pubmed-meshheading:20223948-Enzyme Induction,
pubmed-meshheading:20223948-Epithelial Cells,
pubmed-meshheading:20223948-Extracellular Matrix,
pubmed-meshheading:20223948-Female,
pubmed-meshheading:20223948-Gene Expression Regulation,
pubmed-meshheading:20223948-Insect Proteins,
pubmed-meshheading:20223948-Models, Biological,
pubmed-meshheading:20223948-NADPH Oxidase,
pubmed-meshheading:20223948-Nitric Oxide Synthase,
pubmed-meshheading:20223948-Permeability,
pubmed-meshheading:20223948-Peroxidase,
pubmed-meshheading:20223948-Plasmodium berghei,
pubmed-meshheading:20223948-Plasmodium falciparum,
pubmed-meshheading:20223948-RNA Interference,
pubmed-meshheading:20223948-Tyrosine
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pubmed:year |
2010
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pubmed:articleTitle |
A peroxidase/dual oxidase system modulates midgut epithelial immunity in Anopheles gambiae.
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pubmed:affiliation |
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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