Linked Life Data

20195220

Source:http://linkedlifedata.com/resource/pubmed/id/20195220

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pubmed-article:20195220pubmed:abstractTextSerotonin-selective reuptake inhibitors (SSRIs) have been shown to enhance the locomotor stimulatory, discriminative-stimulus, and convulsive effects of cocaine in rodents. A pharmacokinetic mechanism for the interaction is supported by increases in the brain levels of cocaine by fluoxetine treatment. Furthermore, the locomotor-stimulant effects of cocaine in rodents are enhanced by fluoxetine and fluvoxamine, SSRIs known to inhibit cocaine-metabolizing cytochrome P450 enzymes, whereas citalopram, an SSRI that does not inhibit P450 enzymes, does not enhance cocaine's locomotor-stimulant effects. Citalopram, however, attenuated the discriminative-stimulus effects of cocaine in squirrel monkeys trained to discriminate cocaine from saline, though it enhanced the discriminative-stimulus effects of a low dose of cocaine in rats trained to discriminate high and low doses of the drug. This study investigated the effects of citalopram on cocaine's discriminative-stimulus effects in rats trained more simply to discriminate cocaine from saline. Citalopram alone produced predominantly saline-appropriate responding, but when administered before cocaine, citalopram dose-dependently shifted the cocaine dose-response curve leftward. The present findings suggest that enhancement of cocaine's discriminative-stimulus effects may occur through a mechanism different from that underlying enhancement of cocaine's locomotor effects or that another action of citalopram selectively blocks locomotor enhancement.lld:pubmed
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pubmed-article:20195220pubmed:authorpubmed-author:SotoPaul LPLlld:pubmed
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pubmed-article:20195220pubmed:articleTitleCitalopram enhances cocaine's subjective effects in rats.lld:pubmed
pubmed-article:20195220pubmed:affiliationBehavioral Biology Research Center, Johns Hopkins University, Baltimore, Maryland 21224-6823, USA. psoto@jhmi.edulld:pubmed
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