Linked Life Data

20193848

Source:http://linkedlifedata.com/resource/pubmed/id/20193848

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-3-2
pubmed:abstractText
To determine the possible alteration of the inhibitor kappaBalpha (HUGO-approved symbol, NFKBIA) gene in Chinese Hodgkin lymphoma (HL) patients, NFKBIA mRNA and protein expression in 22 primary HL patients were examined. Individual tumor cells were used for amplification to obtain the NFKBIA gene, and the polymerase chain reaction products were sequenced. Compared with reactive surrounding lymphocytes, inhibitor kappaBalpha protein (IkappaBalpha) expression was weaker in the cytoplasm of H-RS (Hodgkin and Reed-Sternberg) cells. NFKBIA mRNA was strongly expressed in H-RS cells from HL sections, and little was detected in the reactive surrounding lymphocytes. A total of 37.5% of the patients with HL had mutations in the NFKBIA gene. Some mutations possibly resulted in C-terminally truncated form of the IkappaBalpha. These data suggest that the impairment of the IkappaBalpha functions was produced during the pathogenesis of the tumor cell clone in Chinese HL patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1873-4456
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
197
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
152-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Mutations of NFKBIA in biopsy specimens from Hodgkin lymphoma.
pubmed:affiliation
Department of Chemotherapy, Cancer Hospital, Department of Oncology, Shanghai Medical Collage, Fudan University, 270 Dongan Road, Shanghai 200032, P.R. China.
pubmed:publicationType
Journal Article