| pubmed-article:20193704 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20193704 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:20193704 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:20193704 | lifeskim:mentions | umls-concept:C0312853 | lld:lifeskim |
| pubmed-article:20193704 | lifeskim:mentions | umls-concept:C2935387 | lld:lifeskim |
| pubmed-article:20193704 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:20193704 | pubmed:dateCreated | 2010-4-19 | lld:pubmed |
| pubmed-article:20193704 | pubmed:abstractText | To address whether saccharide moieties of blood groups A, B and O antigens modulate hemolytic activity of Naja naja atra cardiotoxins (CTXs), the present study was carried out. Unlike other CTX isotoxins, hemolytic activity of CTX3 toward blood group O cholesterol-depleted red blood cells (RBCs) was notably lower than that of blood groups A and B cholesterol-depleted RBCs. Conversion of blood group B RBCs into blood group O RBCs by alpha-galactosidase treatment attenuated the susceptibility for hemolytic activity of CTX3, suggesting that H-antigen affected hemolytic potency of CTX3. Pre-incubation with H-trisaccharide reduced hemolytic activity and membrane-damaging activity of CTX3. Moreover, CTX3 showed a higher binding capability with H-trisaccharide than other CTXs did. CD spectra showed that the binding with H-trisaccharide induced changes in gross conformation of CTX3. Self-quenching studies revealed that oligomerization of CTX3 was affected in the presence of H-trisaccharide. Taken together, our data suggest that the binding of CTX3 with H-antigen alters its membrane-bound mode, thus reducing its hemolytic activity toward blood group O cholesterol-depleted RBCs. | lld:pubmed |
| pubmed-article:20193704 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20193704 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20193704 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20193704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20193704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20193704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20193704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20193704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20193704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20193704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20193704 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20193704 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20193704 | pubmed:issn | 1879-3150 | lld:pubmed |
| pubmed-article:20193704 | pubmed:author | pubmed-author:LinShinne-Ren... | lld:pubmed |
| pubmed-article:20193704 | pubmed:author | pubmed-author:ChangLong-Sen... | lld:pubmed |
| pubmed-article:20193704 | pubmed:author | pubmed-author:KaoPei-HsiuPH | lld:pubmed |
| pubmed-article:20193704 | pubmed:copyrightInfo | 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20193704 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20193704 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20193704 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:20193704 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20193704 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20193704 | pubmed:pagination | 1387-95 | lld:pubmed |
| pubmed-article:20193704 | pubmed:meshHeading | pubmed-meshheading:20193704... | lld:pubmed |
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| pubmed-article:20193704 | pubmed:meshHeading | pubmed-meshheading:20193704... | lld:pubmed |
| pubmed-article:20193704 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20193704 | pubmed:articleTitle | Interaction of Naja naja atra cardiotoxin 3 with H-trisaccharide modulates its hemolytic activity and membrane-damaging activity. | lld:pubmed |
| pubmed-article:20193704 | pubmed:affiliation | Institute of Biomedical Sciences, National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan. | lld:pubmed |
| pubmed-article:20193704 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20193704 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:20193704 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
