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pubmed-article:2014713rdf:typepubmed:Citationlld:pubmed
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pubmed-article:2014713pubmed:dateCreated1991-5-10lld:pubmed
pubmed-article:2014713pubmed:abstractTextThe tendency to form a beta-turn in alpha-gliadin was estimated using the B-cell determinant prediction program based on the Chou and Fasman probability of beta-turn formation. Six sequences possessing a high probability of beta-turn formation were found. A statistically high agreement was found between these six sequences and three areas in alpha-gliadin with the occurrence of Pro-Ser-Gln-Gln sequence which has recently been considered responsible for toxicity in coeliac disease. By means of solid-phase synthesis seven peptides were obtained covering the above-mentioned regions. Their toxicity was tested using the fetal chick duodenum. The results support the suggestion that peptides containing the sequences Pro-Ser-Gln-Gln and Gln-Gln-Gln-Pro may be involved in the pathogenesis of coeliac disease.lld:pubmed
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pubmed-article:2014713pubmed:issn0044-3026lld:pubmed
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pubmed-article:2014713pubmed:authorpubmed-author:KrchnákVVlld:pubmed
pubmed-article:2014713pubmed:authorpubmed-author:MothesTTlld:pubmed
pubmed-article:2014713pubmed:authorpubmed-author:KocnaPPlld:pubmed
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pubmed-article:2014713pubmed:volume192lld:pubmed
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pubmed-article:2014713pubmed:pagination116-9lld:pubmed
pubmed-article:2014713pubmed:dateRevised2003-11-14lld:pubmed
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pubmed-article:2014713pubmed:year1991lld:pubmed
pubmed-article:2014713pubmed:articleTitleRelationship between gliadin peptide structure and their effect on the fetal chick duodenum.lld:pubmed
pubmed-article:2014713pubmed:affiliationLaboratory of Gastroenterology, Faculty of General Medicine, Charles University, Prague, Czechoslovakia.lld:pubmed
pubmed-article:2014713pubmed:publicationTypeJournal Articlelld:pubmed