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pubmed-article:2013741pubmed:abstractTextMetabolic and isotopic dilution techniques were used to investigate fluid balance and fluid volumes in rats made diabetic with streptozotocin before and after infusion. Uninfused diabetic rats had significantly (P less than 0.01) lower total body water than controls (57.7 +/- 2.2 vs 65.7 +/- 1.4% (S.E.M.) fat free mass). This was due exclusively to a significantly (P less than 0.001) reduced intracellular fluid volume (38.2 +/- 1.5 vs 45.4 +/- 1.4% fat free mass). Metabolic studies over the preceding 2 weeks showed that the fluid deficit in the diabetic group had resulted from a failure of the rats to increase their fluid intake to the same extent as their combined fluid losses. A 4-h saline infusion halved the fluid deficit in diabetic animals. The retained fluid was used to restore intracellular fluid volume which became comparable in diabetic and control rats (47.2 +/- 2.0 vs 46.4 +/- 1.0% fat free mass). The retention of infusate by diabetic animals to counteract their intracellular dehydration may partly explain the reduced urine output reported elsewhere in infused anaesthetized diabetic rats.lld:pubmed
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pubmed-article:2013741pubmed:issn0022-0795lld:pubmed
pubmed-article:2013741pubmed:authorpubmed-author:GarlandH OHOlld:pubmed
pubmed-article:2013741pubmed:authorpubmed-author:AnwanaA BABlld:pubmed
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pubmed-article:2013741pubmed:volume128lld:pubmed
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pubmed-article:2013741pubmed:pagination333-7lld:pubmed
pubmed-article:2013741pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:2013741pubmed:year1991lld:pubmed
pubmed-article:2013741pubmed:articleTitleIntracellular dehydration in the rat made diabetic with streptozotocin: effects of infusion.lld:pubmed
pubmed-article:2013741pubmed:affiliationDepartment of Physiological Sciences, University of Manchester.lld:pubmed
pubmed-article:2013741pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2013741pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed