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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0020538,
umls-concept:C0033414,
umls-concept:C0034693,
umls-concept:C0040624,
umls-concept:C0185117,
umls-concept:C0682972,
umls-concept:C1367690,
umls-concept:C1414313,
umls-concept:C1424729,
umls-concept:C1426330,
umls-concept:C1428424,
umls-concept:C1441654,
umls-concept:C1858854,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2010-6-14
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pubmed:abstractText |
The presence of metabolic abnormalities such as insulin resistance and elevated levels of various vasoconstrictor G-protein-coupled receptor (GPCR) agonists contributes to the development of hypertension. Recent studies have suggested a link between disease progression and activation of growth factor receptor signalling pathways such as the epidermal growth factor receptor (EGFR) by matrix metalloproteinases (MMPs). We hypothesized that excessive stimulation of GPCRs such as alpha(1)-adrenergic receptors activates MMP-dependent EGFR transactivation and contributes to the development of hypertension by promoting increased synthesis of contractile proteins in vascular smooth muscle (VSM).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-1 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Cardiac Myosins,
http://linkedlifedata.com/resource/pubmed/chemical/Egfr protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Fructose,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/Mmp2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Myosin Light Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/myosin light chain 2,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
177-86
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20110336-Adrenergic alpha-1 Receptor Agonists,
pubmed-meshheading:20110336-Adrenergic alpha-Agonists,
pubmed-meshheading:20110336-Animals,
pubmed-meshheading:20110336-Cardiac Myosins,
pubmed-meshheading:20110336-Cells, Cultured,
pubmed-meshheading:20110336-Disease Models, Animal,
pubmed-meshheading:20110336-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:20110336-Fructose,
pubmed-meshheading:20110336-Hypertension,
pubmed-meshheading:20110336-Insulin Resistance,
pubmed-meshheading:20110336-Male,
pubmed-meshheading:20110336-Matrix Metalloproteinase 2,
pubmed-meshheading:20110336-Matrix Metalloproteinase 7,
pubmed-meshheading:20110336-Muscle, Smooth, Vascular,
pubmed-meshheading:20110336-Myocytes, Smooth Muscle,
pubmed-meshheading:20110336-Myosin Light Chains,
pubmed-meshheading:20110336-Phenylephrine,
pubmed-meshheading:20110336-Phosphorylation,
pubmed-meshheading:20110336-Protease Inhibitors,
pubmed-meshheading:20110336-Protein Kinase Inhibitors,
pubmed-meshheading:20110336-RNA Interference,
pubmed-meshheading:20110336-Rats,
pubmed-meshheading:20110336-Rats, Wistar,
pubmed-meshheading:20110336-Receptor, Epidermal Growth Factor,
pubmed-meshheading:20110336-Receptor Cross-Talk,
pubmed-meshheading:20110336-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:20110336-Signal Transduction,
pubmed-meshheading:20110336-Time Factors,
pubmed-meshheading:20110336-Transfection,
pubmed-meshheading:20110336-Up-Regulation,
pubmed-meshheading:20110336-Vasoconstriction,
pubmed-meshheading:20110336-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2010
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pubmed:articleTitle |
GPCR agonist-induced transactivation of the EGFR upregulates MLC II expression and promotes hypertension in insulin-resistant rats.
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pubmed:affiliation |
Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver, BC, Canada, V6T 1Z3.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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