Linked Life Data

20101899

Source:http://linkedlifedata.com/resource/pubmed/id/20101899

Statements in which the resource exists.
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pubmed-article:20101899pubmed:abstractTextPhosphodiesterases are a class of proteins that primarily modulate intracellular levels of cyclic nucleotides such as cGMP and cAMP. Phosphodiesterase-5 (PDE5) is mainly involved in the smooth muscle cell cGMP inactivation. Chemical inhibition of PDE5 has recently become a valid therapeutic option of nitric oxide pathway potentiation via cell cGMP availability. More specifically, PDE5 inhibition appears successful for the treatment of idiopathic pulmonary arterial hypertension. Additional intriguing therapeutic properties are a protective effect on the myocardium through antihypertrophic and antiapoptotic mechanisms and on vascular function by improving endothelial responsiveness and tolerance to myocardial ischemia-reperfusion injury. These effects imply a potential usefulness in the treatment of coronary artery disease and heart failure. Evidence currently available for considering PDE5 inhibition an additional therapeutic opportunity in cardiovascular disorders is provided.lld:pubmed
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pubmed-article:20101899pubmed:articleTitle[Clinical use of phosphodiesterase-5 inhibitors in cardiopulmonary diseases: from experimental evidence to clinical application].lld:pubmed
pubmed-article:20101899pubmed:affiliationUnità Cardiopolmonare, Ospedale San Paolo, Università degli Studi, Milano. marco.guazzi@unimi.itlld:pubmed
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