Linked Life Data

20091820

Source:http://linkedlifedata.com/resource/pubmed/id/20091820

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-4-30
pubmed:abstractText
The aim of this work was to evaluate the low molecular weight chitosans (LMWCs) as enhancers of transdermal administration of baicalin, an useful drug for the treatment of atopic dermatitis, viral hepatitis, and HIV infection. Permeation experiments were performed in vitro through mouse skin by using Franz cells. Improved baicalin skin penetration was obtained with the addition of LMWCs or D-glucosamine (beta-D-GlcNH(2)) to the donor solutions. Chitosan molecular weight, degree of deacetylation, pH of donor baicalin solutions, and enhancer concentration all affected LMWC enhancement effects. Significant enhancement was observed at pH 7.0 or 7.5 for CS80-1000, and the enhancement factor (EF) in the co-delivery method was calculated as 11.7 or 15.9, respectively. Simultaneously, beta-D-GlcNH(2) showed greatest enhancement at pH 7.0 with an EF of 11. Moreover, there was an optimal concentration range (0.5-1% by weight for CS80-1000 and 1.0-1.5% for beta-D-GlcNH(2)) to enhance baicalin transdermal delivery. It was concluded that the effective fractions for the enhancement of LMWCs were beta-D-GlcNH(2) oligomers, and the repeated number of beta-D-GlcNH(2) was suggested to be in the range 2-6. Enhancement mechanism of LMWCs was also discussed and suggested to be relative to the interactions of LMWC with both baicalin and the lipid of stratum corneum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1520-6017
pubmed:author
pubmed:copyrightInfo
(c) 2010 Wiley-Liss, Inc. and the American Pharmacists Association
pubmed:issnType
Electronic
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2991-8
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Effect of low molecular weight chitosans on drug permeation through mouse skin: 1. Transdermal delivery of baicalin.
pubmed:affiliation
School of Chemical Engineering, Tianjin University, Tianjin, China. zhouxueqin@tju.edu.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't