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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-2-17
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pubmed:abstractText |
Placenta-derived oestrogens have an impact on the growth and differentiation of the trophoblast, and are involved in processes initiating and facilitating birth. The enzyme that converts androgens into oestrogens, aromatase cytochrome P450 (P450arom), is encoded by the Cyp19 gene. In the placenta of the cow, expression of Cyp19 relies on promoter 1.1 (P1.1). Our recent studies of P1.1 in vitro and in a human trophoblast cell line (Jeg3) revealed that interactions of placental nuclear protein(s) with the E-box element at position -340 are required for full promoter activity. The aim of this work was to identify and characterise the placental E-box (-340)-binding protein(s) (E-BP) as a step towards understanding how the expression of Cyp19 is regulated in the bovine placenta.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2199
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:20082704-Animals,
pubmed-meshheading:20082704-Aromatase,
pubmed-meshheading:20082704-Cattle,
pubmed-meshheading:20082704-Cell Line,
pubmed-meshheading:20082704-E-Box Elements,
pubmed-meshheading:20082704-Female,
pubmed-meshheading:20082704-Humans,
pubmed-meshheading:20082704-Placenta,
pubmed-meshheading:20082704-Pregnancy,
pubmed-meshheading:20082704-Promoter Regions, Genetic,
pubmed-meshheading:20082704-RNA, Small Interfering,
pubmed-meshheading:20082704-RNA Interference,
pubmed-meshheading:20082704-Transcriptional Activation,
pubmed-meshheading:20082704-Upstream Stimulatory Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Upstream stimulating factors 1 and 2 enhance transcription from the placenta-specific promoter 1.1 of the bovine cyp19 gene.
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pubmed:affiliation |
Research Unit Molecular Biology, Research Institute for the Biology of Farm Animals (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany. fuerbass@fbn-dummerstorf.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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