Linked Life Data

20080845

Source:http://linkedlifedata.com/resource/pubmed/id/20080845

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-3-5
pubmed:abstractText
Context: The cause of preeclampsia remains unknown. Excessive antiangiogenic proteins have been proposed to play a pathogenic role in preeclampsia. Objective: Our objective was to determine the differences in soluble endoglin (sEndoglin), soluble fms-like tyrosine kinase receptor-1 (sFLT1), leptin, adiponectin, and endothelin 1 concentrations between normal and preeclampsia amniotic fluid (AF). Such results may help us understand the pathophysiology of preeclampsia. Methods: We performed a nested case-control study. Seventy-one women with preeclampsia were matched to 71 normotensive controls. The preeclamptic women were broken into two subgroups according to the association with fetal intrauterine growth restriction (IUGR). AF concentrations of sEndoglin, sFLT1, leptin, adiponectin, and endothelin 1 were measured by ELISA. Receiver-operating characteristics curve analysis was used to compare the discriminative values of these potential biomarkers. Functional network analysis was performed using MetaCore to reveal the common functions of the interacting proteins. Results: Increased AF concentrations of sFLT1, sEndoglin, endothelin 1, and leptin were found in women who later developed preeclampsia. sFLT1, sEndoglin, leptin, and adiponectin were significantly higher in the preeclampsia with IUGR than those without IUGR. Leptin has the largest area under the curve (0.753). Network analysis revealed that elevated amniotic proteins are involved in the inflammatory process of the human placenta. Conclusions: Significant elevation of leptin can be detected in AF 2 months earlier than the appearance of symptoms; thus, it may be used as a predictive marker for preeclampsia. The increase of these antiangiogenic proteins supports the roles of inflammation and oxidative stress in pathogenesis of preeclampsia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1945-7197
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1431-41
pubmed:meshHeading
pubmed-meshheading:20080845-Adiponectin, pubmed-meshheading:20080845-Adult, pubmed-meshheading:20080845-Amniotic Fluid, pubmed-meshheading:20080845-Analysis of Variance, pubmed-meshheading:20080845-Antigens, CD, pubmed-meshheading:20080845-Case-Control Studies, pubmed-meshheading:20080845-Chi-Square Distribution, pubmed-meshheading:20080845-Endothelin-1, pubmed-meshheading:20080845-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:20080845-Female, pubmed-meshheading:20080845-Fetal Growth Retardation, pubmed-meshheading:20080845-Humans, pubmed-meshheading:20080845-Leptin, pubmed-meshheading:20080845-Pre-Eclampsia, pubmed-meshheading:20080845-Predictive Value of Tests, pubmed-meshheading:20080845-Pregnancy, pubmed-meshheading:20080845-Prospective Studies, pubmed-meshheading:20080845-ROC Curve, pubmed-meshheading:20080845-Receptors, Cell Surface, pubmed-meshheading:20080845-Regression Analysis, pubmed-meshheading:20080845-Vascular Endothelial Growth Factor Receptor-1
pubmed:year
2010
pubmed:articleTitle
Change in amniotic fluid levels of multiple anti-angiogenic proteins before development of preeclampsia and intrauterine growth restriction.
pubmed:affiliation
No.5, Fu-Shin Road, Gwei-Shan, Tao-Yuan 333, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't