Linked Life Data

20051643

Source:http://linkedlifedata.com/resource/pubmed/id/20051643

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-1-6
pubmed:abstractText
We conducted two studies to examine the hypothesis that lower urinary tract obstruction induces excessive production of prostaglandin E2 (PGE2) in the bladder in young boys, with consequent overactive bladder (OAB) symptoms. The subjects were boys aged less than 15 years old who were scheduled to undergo surgery in our department from October 2006 to March 2008. In study 1 (n=25), the patients were divided into two groups based on the presence or absence of lower urinary tract obstruction. In study 2 (n=38), the patients were classified by age. The PGE2 level in the bladder was determined by washing with saline before the operation and urinary symptoms were evaluated using the Pediatric Lower Urinary Tract Scoring System. In study 1, the PGE2 level in the bladder of patients with lower urinary tract obstruction was higher than in those without obstruction (49.1+/-37.4 vs. 21.5+/-10.1 pg/mL, P=0.0475). In study 2, the PGE2 level in the bladder was negatively correlated with age (r=-0.379, P=0.0207). A higher level of PGE2 is found in boys with bladder outlet obstruction due to urethral stricture and in younger boys, and this elevated level of PGE2 may induce OAB symptoms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1880-313X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
343-7
pubmed:dateRevised
2011-4-22
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
A higher level of prostaglandin E2 in the urinary bladder in young boys and boys with lower urinary tract obstruction.
pubmed:affiliation
Department of Urology, Nara Medical University, Nara, Japan.
pubmed:publicationType
Journal Article