Linked Life Data

2003559

Source:http://linkedlifedata.com/resource/pubmed/id/2003559

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-4-15
pubmed:abstractText
Symptomatic hypovolemia in preeclampsia is often treated by volume expansion. However, the effect of this treatment on placental blood flow is unclear. In the present study the hypothesis was tested that slow volume expansion, imposed on volume-depleted rats, does not compromise placental blood flow. Mild hypovolemia was induced in rats in late pregnancy by 24 hours' thirsting. The resulting gradual dehydration was associated with a 7% reduction in blood volume. These rats were then subjected to blood volume expansion by a continuous infusion with a plasma substitute. Volume expansion increased blood volume by 32% and cardiac output by 73%. The extra cardiac output was distributed to kidneys, carcass, and portal bed. Placental blood flow decreased by 31%. The pattern of response was comparable to the one previously observed in normovolemic rats. However, the magnitude of the changes was larger, probably associated with a delayed or impaired diuretic response. These data suggest that volume expansion therapy in mildly hypovolemic pregnant rats elicits an exaggerated hemodynamic response as compared with normovolemic rats, including placental compromise.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0002-9378
pubmed:author
pubmed:issnType
Print
pubmed:volume
164
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
921-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
The effect of volume expansion on placental blood flow in awake hypovolemic rats in late pregnancy.
pubmed:affiliation
Department of Obstetrics and Gynecology, University of Limburg, Maastricht, The Netherlands.
pubmed:publicationType
Journal Article