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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-5
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pubmed:abstractText |
Peritoneal dissemination of gastric cancer is often refractory to systemic therapies. Although adenoviral gene therapy has been reported to be a potentially useful therapeutic modality, the adenovirus itself has a dose-limiting toxicity. A novel system was constructed using adenoviral oncolytic suicide gene therapy targeting carcinoembryonic antigen (CEA), and its therapeutic effect and the possibility to reduce the total viral dose while still preserving the antitumor effect were assessed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1534-4681
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pubmed:author |
pubmed-author:BabaHideoH,
pubmed-author:HayashiNaokoN,
pubmed-author:HirashimaKotaroK,
pubmed-author:HiyoshiYukiharuY,
pubmed-author:ImamuraYuY,
pubmed-author:IshikawaShinjiS,
pubmed-author:KarashimaRyuichiR,
pubmed-author:KogaYoshikatsuY,
pubmed-author:NagaiYouheiY,
pubmed-author:SatoNobutakaN,
pubmed-author:WatanabeMasayukiM,
pubmed-author:YamadaGenG
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pubmed:issnType |
Electronic
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
643-52
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pubmed:meshHeading |
pubmed-meshheading:20012217-Adenoviridae,
pubmed-meshheading:20012217-Animals,
pubmed-meshheading:20012217-Carcinoembryonic Antigen,
pubmed-meshheading:20012217-Female,
pubmed-meshheading:20012217-Gene Therapy,
pubmed-meshheading:20012217-Genetic Vectors,
pubmed-meshheading:20012217-Humans,
pubmed-meshheading:20012217-Immunoenzyme Techniques,
pubmed-meshheading:20012217-Integrases,
pubmed-meshheading:20012217-Mice,
pubmed-meshheading:20012217-Mice, Inbred BALB C,
pubmed-meshheading:20012217-Mice, Nude,
pubmed-meshheading:20012217-Oncolytic Virotherapy,
pubmed-meshheading:20012217-Peritoneal Neoplasms,
pubmed-meshheading:20012217-Stomach Neoplasms,
pubmed-meshheading:20012217-Survival Rate,
pubmed-meshheading:20012217-Tumor Cells, Cultured,
pubmed-meshheading:20012217-Xenograft Model Antitumor Assays
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pubmed:year |
2010
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pubmed:articleTitle |
Adenoviral oncolytic suicide gene therapy for a peritoneal dissemination model of gastric cancer in mice.
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pubmed:affiliation |
Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-City, Kumamoto, Japan.
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pubmed:publicationType |
Journal Article
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