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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1991-4-11
|
| pubmed:abstractText |
Animal and human studies have suggested a thermogenic synergism between ephedrine (E), a beta-agonist, and caffeine (C), an adenosine antagonist, which may be suitable for the treatment of obesity. To study this phenomenon, the thermogenic effect of single doses of oral placebo, E 10 mg, E 20 mg, C 100 mg, and C 200 mg were compared with the effects of three different combinations of E + C, 10 mg/200 mg, 20 mg/100 mg, and 20 mg/200 mg, measured by indirect calorimetry in six healthy, lean subjects. The thermogenic effect after E + C 20 mg/200 mg was larger than that of any of the other combinations. In this dose ratio, ephedrine and caffeine exerted a supra-additive synergism, whereas the thermogenic effects of the other two combinations were only additive. The 3-hour postintake increase in systolic blood pressure after all three combinations averaged 5 to 7 mm Hg more than placebo (P less than .01), which exceeded the predicted additive effect fivefold to sevenfold. Diastolic blood pressure was not increased by E + C 20 mg/200 mg, whereas the other two combinations increased it by approximately 4 mm Hg more than placebo. E + C 20 mg/100 mg and 20 mg/200 mg increased heart rate more than placebo, while E + C 10 mg/200 mg had no effect on heart rate. As expected, all combinations increased plasma glucose, insulin, and C-peptide from their ephedrine content. No significant effects of the combinations were found on plasma lactate, glycerol, nonesterified fatty acids (NEFA), triglyceride, potassium, or sodium.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Caffeine,
http://linkedlifedata.com/resource/pubmed/chemical/Electrolytes,
http://linkedlifedata.com/resource/pubmed/chemical/Ephedrine,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Lactates,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Placebos
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0026-0495
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
323-9
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2000046-Adult,
pubmed-meshheading:2000046-Blood Glucose,
pubmed-meshheading:2000046-Blood Pressure,
pubmed-meshheading:2000046-Body Temperature Regulation,
pubmed-meshheading:2000046-C-Peptide,
pubmed-meshheading:2000046-Caffeine,
pubmed-meshheading:2000046-Double-Blind Method,
pubmed-meshheading:2000046-Drug Synergism,
pubmed-meshheading:2000046-Electrolytes,
pubmed-meshheading:2000046-Energy Metabolism,
pubmed-meshheading:2000046-Ephedrine,
pubmed-meshheading:2000046-Female,
pubmed-meshheading:2000046-Heart Rate,
pubmed-meshheading:2000046-Humans,
pubmed-meshheading:2000046-Insulin,
pubmed-meshheading:2000046-Lactates,
pubmed-meshheading:2000046-Lactic Acid,
pubmed-meshheading:2000046-Lipids,
pubmed-meshheading:2000046-Male,
pubmed-meshheading:2000046-Placebos,
pubmed-meshheading:2000046-Reference Values
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Thermogenic synergism between ephedrine and caffeine in healthy volunteers: a double-blind, placebo-controlled study.
|
| pubmed:affiliation |
Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|