Linked Life Data

1995617

Source:http://linkedlifedata.com/resource/pubmed/id/1995617

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-3-27
pubmed:databankReference
pubmed:abstractText
Glutamine/glutamic-acid rich proteins (GRPs) are a family of rat submandibular gland acinar proteins which are secreted in response to beta-adrenergic agonists such as isoproterenol. Two forms of GRP transcripts have been identified by isolating plasmids containing cDNAs which code for two distinct GRPs, termed GRP-Ca and GRP-Cb. GRP-Ca and GRP-Cb have identical sequences up to nucleotide 670. This is followed by a unique 90- (GRP-Ca) or 95- (GRP-Cb) base pair element. Both forms have common 3' nucleotide sequences, although the GRP-Cb stop codon is 27 base pairs further 3' from the start site of transcription. Systemic exposure to isoproterenol results in a decrease in the relative steady-state level of GRP-Ca transcripts within 24 h, whereas GRP-Cb message increases after several days of isoproterenol treatment. The demonstration that secretagogues such as isoproterenol can modulate changes in salivary protein expression suggests that the machinery responsible for exocytosis is functionally coupled to the cellular apparatus involved in acinar protein production.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
266
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3532-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Secretagogue-coupled changes in the expression of glutamine/glutamic acid-rich proteins (GRPs). Isoproterenol induces changes in GRP transcript expression and changes in isoforms secreted.
pubmed:affiliation
Department of Dental Research, School of Medicine and Dentistry, University of Rochester, New York 14642.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.