Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
48
pubmed:dateCreated
2009-12-3
pubmed:abstractText
Little is known of microRNA interactions with cellular pathways. Few reports have associated microRNAs with the Notch pathway, which plays key roles in nervous system development and in brain tumors. We previously implicated the Notch pathway in gliomas, the most common and aggressive brain tumors. While investigating Notch mediators, we noted microRNA-326 was upregulated following Notch-1 knockdown. This neuronally expressed microRNA was not only suppressed by Notch but also inhibited Notch proteins and activity, indicating a feedback loop. MicroRNA-326 was downregulated in gliomas via decreased expression of its host gene. Transfection of microRNA-326 into both established and stem cell-like glioma lines was cytotoxic, and rescue was obtained with Notch restoration. Furthermore, miR-326 transfection reduced glioma cell tumorigenicity in vivo. Additionally, we found microRNA-326 partially mediated the toxic effects of Notch knockdown. This work demonstrates a microRNA-326/Notch axis, shedding light on the biology of Notch and suggesting microRNA-326 delivery as a therapy.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-10839358, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-10850492, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-11907276, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-12529645, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-12627324, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-14691248, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-15105502, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-15137944, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-15145345, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-15472075, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-15531372, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-15781650, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-15833912, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-16009126, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-16024602, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-16039986, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-16192569, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-16239437, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-16452208, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-16697959, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-16762633, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-17540598, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-17540599, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-17554337, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-17584857, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-17974965, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-18483236, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-18756266, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-18973228, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-7956822, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-9032325, http://linkedlifedata.com/resource/pubmed/commentcorrection/19955368-9285721
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
2
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15161-8
pubmed:dateRevised
2011-11-9
pubmed:meshHeading
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