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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1991-3-15
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pubmed:abstractText |
Changes in the 3H-thymidine labelling index (3H-TdR LI) of primary tumor induced by cytoreductive chemotherapy were evaluated in 26 patients with locally advanced breast cancer subjected to mastectomy after different systemic therapies. A significant reduction of 3H-TdR LI by primary chemotherapy was observed in 11 cases. Changes in cell kinetics were related to the pretreatment proliferative activity: significant increases were observed in 70% of tumors with a very low 3H-TdR LI (less than 25%) and significant decreases in 100% of tumors with a very high 3H-TdR LI (greater than 7.0%). There was no correlation between pretreatment 3H-TdR LI and the objective clinical response, which was conversely related to posttreatment cell kinetics. The 2-year progression rate was lower for patients whose residual tumors after treatment had remained (2/7) or become (1/8) slowly proliferating than for patients whose tumors had remained (5/7) or become (4/4) rapidly proliferating.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
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pubmed:issn |
0020-7136
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
47
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
380-3
|
pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:1993544-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1993544-Breast Neoplasms,
pubmed-meshheading:1993544-Cell Cycle,
pubmed-meshheading:1993544-Cell Division,
pubmed-meshheading:1993544-Female,
pubmed-meshheading:1993544-Humans,
pubmed-meshheading:1993544-Thymidine,
pubmed-meshheading:1993544-Time Factors,
pubmed-meshheading:1993544-Tritium
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pubmed:year |
1991
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pubmed:articleTitle |
Changes in cell kinetics induced by primary chemotherapy in breast cancer.
|
pubmed:affiliation |
Istituto Nazionale Tumori, Milan, Italy.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|