Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-3-26
pubmed:abstractText
We evaluated the radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy. 102 consecutive patients with femoral metastases without pathological fracture were treated by surgery or radiotherapy between 2002 and 2005. Twelve of them initially treated with surgery were excluded from this study. The remaining 90 patients with 102 lesions underwent radiation therapy as the initial treatment. Twelve patients who died within 30 days by disease progression and 6 who were lost to follow-up were excluded. The remaining 72 patients with 84 lesions including 43 impending fractures were enrolled in this analysis. Radiological changes were categorized into complete response, partial response, no change, and progressive disease based on plain radiograph findings. Pain relief was reviewed for 77 painful lesions. The median radiation dose was 30 Gy. No re-irradiation was performed. 35 lesions (42%) achieved radiological responses median 3 months after radiotherapy. Pain relief was obtained in 36 of 77 lesions (47%). There was no significant correlation between radiological response and pain relief (P = 0.166). Eleven lesions eventually required surgery and considered as treatment failure. The treatment failure rate in the radiological progressive disease (PD) group (8/19, 42%) was significantly higher than that in the non-PD group (3/65, 5%) (P < 0.001). Among 43 impending fracture lesions, 15 lesions (36%) experienced radiological response and 35 lesions (81%) required no surgical interventions. Our data suggest that radiotherapy can enable metastatic bone healing and avoid surgery in many lesions. However, radiological PD lesions often require surgery after radiotherapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0449-3060
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-6
pubmed:dateRevised
2011-3-25
pubmed:meshHeading
pubmed-meshheading:19934590-Adult, pubmed-meshheading:19934590-Aged, pubmed-meshheading:19934590-Aged, 80 and over, pubmed-meshheading:19934590-Antineoplastic Agents, pubmed-meshheading:19934590-Bone Neoplasms, pubmed-meshheading:19934590-Carcinoma, pubmed-meshheading:19934590-Combined Modality Therapy, pubmed-meshheading:19934590-Diphosphonates, pubmed-meshheading:19934590-Disease Progression, pubmed-meshheading:19934590-Dose Fractionation, pubmed-meshheading:19934590-Female, pubmed-meshheading:19934590-Femur, pubmed-meshheading:19934590-Follow-Up Studies, pubmed-meshheading:19934590-Fractures, Spontaneous, pubmed-meshheading:19934590-Humans, pubmed-meshheading:19934590-Male, pubmed-meshheading:19934590-Middle Aged, pubmed-meshheading:19934590-Osteolysis, pubmed-meshheading:19934590-Pain, pubmed-meshheading:19934590-Palliative Care, pubmed-meshheading:19934590-Retrospective Studies, pubmed-meshheading:19934590-Treatment Outcome
pubmed:year
2010
pubmed:articleTitle
Radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy.
pubmed:affiliation
Division of Radiation Oncology, Shizuoka Cancer Center, Shizuoka, Japan. h.harada@scchr.jp
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Evaluation Studies