Linked Life Data

19934372

Source:http://linkedlifedata.com/resource/pubmed/id/19934372

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-11-25
pubmed:abstractText
gamma Glutamyl transferase (GGT) and albumin (ALB) are two markers of liver function. These two proteins have been associated with non-alcoholic fatty liver disease and cardiovascular disease. The objectives of this study were to explore the genetic factors that influence variation in the plasma levels of GGT and ALB and to evaluate their genetic correlations with cardiovascular risk factors. Baboons from the Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX, were used as an animal model. The baboons were fed a standard monkey chow diet ad libitum. Fasting plasma concentrations of GGT, ALB, triglycerides, total cholesterol and LDL cholesterol were measured in 350 pedigreed adult baboons by standard assay procedures. A maximum likelihood-based variance decomposition approach implemented in the computer program SOLAR was used to conduct genetic analyses. The heritabilities of GGT (h(2) = 0.55; P < 0.0001) and ALB (h(2) = 0.42; P < 0.01) were significant. No statistically significant associations were found between GGT and the cardiovascular-related phenotypes. Genetic correlations between ALB and total cholesterol, LDL cholesterol and triglycerides were significant. A QTL (LOD = 2.8) for GGT plasma levels was identified on the baboon homologue of human chromosome 22 between markers D22S304 and D22S280. A QTL (LOD = 2.3) near marker D10S1432 was detected on the baboon homologue of human chromosome 10 for ALB. These results imply that variations in the plasma levels of GGT and ALB are under significant genetic regulation and that a common genetic component influences ALB and cardiovascular risk factor phenotypes.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/C06 RR013556, http://linkedlifedata.com/resource/pubmed/grant/C06 RR013556-01, http://linkedlifedata.com/resource/pubmed/grant/C06 RR014578, http://linkedlifedata.com/resource/pubmed/grant/C06 RR014578-01, http://linkedlifedata.com/resource/pubmed/grant/C06 RR015456, http://linkedlifedata.com/resource/pubmed/grant/C06 RR015456-01A1, http://linkedlifedata.com/resource/pubmed/grant/C06 RR017515, http://linkedlifedata.com/resource/pubmed/grant/C06 RR017515-01A1, http://linkedlifedata.com/resource/pubmed/grant/P01 HL028972, http://linkedlifedata.com/resource/pubmed/grant/P01 HL028972-27, http://linkedlifedata.com/resource/pubmed/grant/P01 HL028972-28, http://linkedlifedata.com/resource/pubmed/grant/P51 RR013986, http://linkedlifedata.com/resource/pubmed/grant/P51 RR013986-057109, http://linkedlifedata.com/resource/pubmed/grant/P51 RR013986-11
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1535-3699
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
234
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
vi, 1519-24
pubmed:dateRevised
2011-3-3
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Quantitative loci regulating plasma levels of gamma glutamyl transferase and albumin and their genetic correlations with cardiovascular risk factors.
pubmed:affiliation
Division of Nutritional Sciences, Department of Human Ecology, The University of Texas at Austin,Austin, Texas 78712, USA. tbose@calpoly.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural