| pubmed-article:19925880 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19925880 | lifeskim:mentions | umls-concept:C0016677 | lld:lifeskim |
| pubmed-article:19925880 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19925880 | lifeskim:mentions | umls-concept:C1159816 | lld:lifeskim |
| pubmed-article:19925880 | lifeskim:mentions | umls-concept:C1326203 | lld:lifeskim |
| pubmed-article:19925880 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19925880 | pubmed:dateCreated | 2010-2-9 | lld:pubmed |
| pubmed-article:19925880 | pubmed:abstractText | Francisella tularensis induces apoptosis within macrophages but the temporal and spatial modulation through activation of caspase-1, caspase-3, and the anti-apoptosis nuclear transcription factor B (NF-kappaB) is not known. Whether escape of the bacteria into the cytosol is sufficient and/or essential for activation of NF-kappaB is not known. Our results show that F. tularensis subsp. novicida induces sustained nuclear translocation of NF-kappaB at early time points after infection of human monocytes derived macrophages (hMDMs). The sustained nuclear translocation of NF-kappaB is defective in the iglC mutant that fails to escape into the cytosol of macrophages. Nuclear translocation of NF-kappaB by the wild type strain is abolished upon treatment with the NF-kappaB inhibitor caffein acid phenyl ester. While the wild type strain triggers caspase-3 and caspase-1 activation by 6 h post-infection the iglC mutant is defective in triggering both caspases. In hMDMs treated with the apoptosis-inducing agent, staurosporin, there is an induction of cell death in the iglC mutant-infected macrophages despite reduced frequency of caspase-1 and caspase-3 activity. The wt-infected macrophages are resistant to cell death-induced agent. We conclude that although caspase-1 and capsase-3 are triggered within F. tularensis-infected hMDMs during early stages of infection, cell death is delayed, which is correlated with simultaneous activation of NF-kappaB. | lld:pubmed |
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| pubmed-article:19925880 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19925880 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19925880 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19925880 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19925880 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19925880 | pubmed:issn | 1769-714X | lld:pubmed |
| pubmed-article:19925880 | pubmed:author | pubmed-author:KwaikYousef... | lld:pubmed |
| pubmed-article:19925880 | pubmed:author | pubmed-author:SanticMarinaM | lld:pubmed |
| pubmed-article:19925880 | pubmed:author | pubmed-author:JonesSnakeS | lld:pubmed |
| pubmed-article:19925880 | pubmed:author | pubmed-author:AsareRexfordR | lld:pubmed |
| pubmed-article:19925880 | pubmed:author | pubmed-author:PavokovicGord... | lld:pubmed |
| pubmed-article:19925880 | pubmed:copyrightInfo | Copyright 2009 Elsevier Masson SAS. All rights reserved. | lld:pubmed |
| pubmed-article:19925880 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19925880 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:19925880 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19925880 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19925880 | pubmed:pagination | 126-34 | lld:pubmed |
| pubmed-article:19925880 | pubmed:dateRevised | 2011-7-22 | lld:pubmed |
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| pubmed-article:19925880 | pubmed:meshHeading | pubmed-meshheading:19925880... | lld:pubmed |
| pubmed-article:19925880 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19925880 | pubmed:articleTitle | Regulation of apoptosis and anti-apoptosis signalling by Francisella tularensis. | lld:pubmed |
| pubmed-article:19925880 | pubmed:affiliation | Department of Microbiology and Parasitology, University of Rijeka, Medical Faculty, Brace Branchetta 20, 51000 Rijeka, Croatia. marina@medri.hr | lld:pubmed |
| pubmed-article:19925880 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19925880 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19925880 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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