Linked Life Data

19881498

Source:http://linkedlifedata.com/resource/pubmed/id/19881498

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-11-25
pubmed:abstractText
Photosensitive caged compounds have enhanced our ability to address the complexity of biological systems by generating effectors with remarkable spatial/temporal resolutions. The caging effect is typically removed by photolysis with ultraviolet light to liberate the bioactive species. Although this technique has been successfully applied to many biological problems, it suffers from a number of intrinsic drawbacks. For example, it requires dedicated efforts to design and synthesize a precursor compound for each effector. The ultraviolet light may cause damage to biological samples and is suitable only for in vitro studies because of its quick attenuation in tissue. Here we address these issues by developing a platform based on the photothermal effect of gold nanocages. Gold nanocages represent a class of nanostructures with hollow interiors and porous walls. They can have strong absorption (for the photothermal effect) in the near-infrared while maintaining a compact size. When the surface of a gold nanocage is covered with a smart polymer, the pre-loaded effector can be released in a controllable fashion using a near-infrared laser. This system works well with various effectors without involving sophisticated syntheses, and is well suited for in vivo studies owing to the high transparency of soft tissue in the near-infrared region.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-11283581, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-11755703, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-11780128, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-12069165, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-15755097, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-15826011, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-16019899, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-16218713, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-16362056, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-16370371, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-16471708, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-17105266, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-17430005, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-18543914, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-18570442, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-18834184, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-19206368, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-19206408, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-8466191, http://linkedlifedata.com/resource/pubmed/commentcorrection/19881498-9434274
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1476-1122
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
935-9
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Gold nanocages covered by smart polymers for controlled release with near-infrared light.
pubmed:affiliation
Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural