rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-3-26
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pubmed:abstractText |
It has been proposed that elements of the renin angiotensin system expressed in the arterial wall are critical for the development of atherosclerosis. Angiotensin converting enzyme (ACE) is highly expressed by the endothelium and is responsible for a critical enzymatic step in the generation of angiotensin II. However, the functional contribution of ACE expression in the vascular wall in atherogenesis is unknown. Therefore, we made use of unique genetic models in which mice without the expression of ACE in the vascular wall were crossed with ApoE(-/-) mice in order to determine the contribution of tissue ACE expression to atherosclerotic lesion formation.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/K99 HL088000,
http://linkedlifedata.com/resource/pubmed/grant/P01 HL058000-060004,
http://linkedlifedata.com/resource/pubmed/grant/P01 HL058000-070004,
http://linkedlifedata.com/resource/pubmed/grant/P01 HL058000-080004,
http://linkedlifedata.com/resource/pubmed/grant/P01 HL058000-090004,
http://linkedlifedata.com/resource/pubmed/grant/P01 HL058000-100004,
http://linkedlifedata.com/resource/pubmed/grant/P01 HL58000,
http://linkedlifedata.com/resource/pubmed/grant/R00 HL088000-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK039777,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK051445,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL070531-09,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL090584,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL090584-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL090584-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL090584-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL70531
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19880118-10075381,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19880118-9833876
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
pubmed:issn |
1879-1484
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pubmed:author |
|
pubmed:copyrightInfo |
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
209
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
352-8
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pubmed:dateRevised |
2011-7-27
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pubmed:meshHeading |
|
pubmed:year |
2010
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pubmed:articleTitle |
Vascular wall ACE is not required for atherogenesis in ApoE(-/-) mice.
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pubmed:affiliation |
Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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