| pubmed-article:19875977 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19875977 | lifeskim:mentions | umls-concept:C0017636 | lld:lifeskim |
| pubmed-article:19875977 | lifeskim:mentions | umls-concept:C1654934 | lld:lifeskim |
| pubmed-article:19875977 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:19875977 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:19875977 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:19875977 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:19875977 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:19875977 | pubmed:dateCreated | 2009-11-26 | lld:pubmed |
| pubmed-article:19875977 | pubmed:abstractText | B7 homolog 1 (B7-H1) is a recently discovered immunoresistance protein that is regulated posttranscriptionally after PTEN loss in malignant glioma, a deadly form of brain tumor. Here, the impact of gamma-interferon-mediated activation of B7-H1 was investigated in glioblastoma patients with PTEN loss. Lymphocytes and T cells were selected for apoptosis assays after 1 : 1 coculture with autologous glioma cells. Gamma interferon treatment of PTEN-deficient tumors resulted in superinduction of B7-H1 protein that correlated with increased T-cell apoptosis, an effect dependent upon activation of the PI3-kinase pathway. The combination of PTEN loss and gamma-interferon exposure in glioblastoma patients results in an exceptionally immunoresistant phenotype that may negate adaptive immunity through induction of T-cell apoptosis. | lld:pubmed |
| pubmed-article:19875977 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19875977 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19875977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875977 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19875977 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19875977 | pubmed:issn | 1473-558X | lld:pubmed |
| pubmed-article:19875977 | pubmed:author | pubmed-author:ParsaAndrew... | lld:pubmed |
| pubmed-article:19875977 | pubmed:author | pubmed-author:YangIsaacI | lld:pubmed |
| pubmed-article:19875977 | pubmed:author | pubmed-author:PieperRussell... | lld:pubmed |
| pubmed-article:19875977 | pubmed:author | pubmed-author:WaldronJames... | lld:pubmed |
| pubmed-article:19875977 | pubmed:author | pubmed-author:FangShannaS | lld:pubmed |
| pubmed-article:19875977 | pubmed:author | pubmed-author:CraneCourtney... | lld:pubmed |
| pubmed-article:19875977 | pubmed:author | pubmed-author:HanSeunggu... | lld:pubmed |
| pubmed-article:19875977 | pubmed:author | pubmed-author:AhnBrian JBJ | lld:pubmed |
| pubmed-article:19875977 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19875977 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:19875977 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:19875977 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19875977 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19875977 | pubmed:pagination | 1597-602 | lld:pubmed |
| pubmed-article:19875977 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
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| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
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| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
| pubmed-article:19875977 | pubmed:meshHeading | pubmed-meshheading:19875977... | lld:pubmed |
| pubmed-article:19875977 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19875977 | pubmed:articleTitle | Gamma interferon-mediated superinduction of B7-H1 in PTEN-deficient glioblastoma: a paradoxical mechanism of immune evasion. | lld:pubmed |
| pubmed-article:19875977 | pubmed:affiliation | Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94117, USA. | lld:pubmed |
| pubmed-article:19875977 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19875977 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19875977 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
