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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1991-2-7
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pubmed:abstractText |
A case-control design involving only cases may be used when brief exposure causes a transient change in risk of a rare acute-onset disease. The design resembles a retrospective nonrandomized crossover study but differs in having only a sample of the base population-time. The average incidence rate ratio for a hypothesized effect period following the exposure is estimable using the Mantel-Haenszel estimator. The duration of the effect period is assumed to be that which maximizes the rate ratio estimate. Self-matching of cases eliminates the threat of control-selection bias and increases efficiency. Pilot data from a study of myocardial infarction onset illustrate the control of within-individual confounding due to temporal association of exposures.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0002-9262
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
144-53
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1985444-Bias (Epidemiology),
pubmed-meshheading:1985444-Case-Control Studies,
pubmed-meshheading:1985444-Confounding Factors (Epidemiology),
pubmed-meshheading:1985444-Humans,
pubmed-meshheading:1985444-Research Design,
pubmed-meshheading:1985444-Retrospective Studies,
pubmed-meshheading:1985444-Risk Factors,
pubmed-meshheading:1985444-Time Factors
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pubmed:year |
1991
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pubmed:articleTitle |
The case-crossover design: a method for studying transient effects on the risk of acute events.
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pubmed:affiliation |
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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