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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-3-10
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pubmed:abstractText |
We have developed and validated quantitative ELISAs for human angiopoietin-like (ANGPTL)3 and 4 and correlated their serum levels with parameters of lipid and carbohydrate metabolism. For this study, we used a random subsample of the Health 2000 Health Examination Survey consisting of 125 men and 125 women, aged 30-94 years. The anthropometric and biochemical parameters of subjects were characterized in detail. ANGPTL 3 and 4 levels were determined using the developed ELISAs. The intra- and inter-assay coefficients of variation for the assays were less than 15%. The average serum concentration of ANGPTL3 was 368 +/- 168 ng/ml (mean +/- SD) and for ANGPTL4 it was 18 +/- 23 ng/ml (mean +/- SD). ANGPTL4 serum levels displayed high variability between individuals ranging from 2 to 158 ng/ml. In post-heparin plasma, both ANGPTL 3 and 4 were increased. Low levels of ANGPTL3 were associated with decreased HDL-cholesterol and increased triglyceride levels. ANGPTL4 levels were positively correlated with FFAs (P = 0.044) and waist-hip ratio (P = 0.016). The developed ELISAs will be important tools to clarify the role of ANGPTL 3 and 4 in human energy metabolism and partitioning of triglycerides between sites of storage (adipose tissue) and oxidation (skeletal and cardiac muscle).
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19826106-10192396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19826106-10644446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19826106-10862772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19826106-12097324,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19826106-12454259,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19826106-14907713,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19826106-16157765,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19826106-17391148,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19826106-3899825
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-2275
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
824-31
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pubmed:dateRevised |
2011-7-27
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pubmed:meshHeading |
pubmed-meshheading:19826106-Adult,
pubmed-meshheading:19826106-Aged,
pubmed-meshheading:19826106-Aged, 80 and over,
pubmed-meshheading:19826106-Angiopoietins,
pubmed-meshheading:19826106-Cell Line,
pubmed-meshheading:19826106-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19826106-Female,
pubmed-meshheading:19826106-Finland,
pubmed-meshheading:19826106-Health Surveys,
pubmed-meshheading:19826106-Heparin,
pubmed-meshheading:19826106-Humans,
pubmed-meshheading:19826106-Lipids,
pubmed-meshheading:19826106-Male,
pubmed-meshheading:19826106-Middle Aged,
pubmed-meshheading:19826106-Overweight,
pubmed-meshheading:19826106-Reproducibility of Results,
pubmed-meshheading:19826106-Sex Characteristics,
pubmed-meshheading:19826106-Time Factors,
pubmed-meshheading:19826106-Waist-Hip Ratio
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pubmed:year |
2010
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pubmed:articleTitle |
Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample.
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pubmed:affiliation |
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Public Health Genomics Research Unit, Biomedicum, Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Validation Studies
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