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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2009-11-17
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pubmed:abstractText |
Galectin-3 plays a role in atherosclerotic diseases, and the effect of adiponectin that protects from atherosclerotic diseases on monocytic galectin-3 was analysed. Adiponectin reduced galectin-3 mRNA, its cellular and soluble form, and this effect was impaired in T2D cells. Cellular galectin-3 was higher in monocytes of overweight than normal-weight donors and was highest in T2D cells. Cellular galectin-3 positively correlated with the BMI of the donors and negatively with soluble monocyte galectin-3. Circulating levels of total adiponectin did not correlate with cellular or soluble galectin-3 indicating that additional factors contribute to higher cellular monocytic galectin-3 in obesity and T2D.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/(6-(4-(2-piperidin-1-ylethoxy)phenyl...,
http://linkedlifedata.com/resource/pubmed/chemical/AICA ribonucleotide,
http://linkedlifedata.com/resource/pubmed/chemical/Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Aminoimidazole Carboxamide,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Galectin 3,
http://linkedlifedata.com/resource/pubmed/chemical/Metformin,
http://linkedlifedata.com/resource/pubmed/chemical/Oleic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Palmitic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleotides
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1873-3468
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pubmed:author |
pubmed-author:BalaMargaritaM,
pubmed-author:BuechlerChristaC,
pubmed-author:KoppAndreaA,
pubmed-author:NeumeierMarkusM,
pubmed-author:SchäfflerAndreasA,
pubmed-author:SporrerDanielaD,
pubmed-author:StögbauerFabianF,
pubmed-author:WanningerJosefJ,
pubmed-author:WeberMarkusM,
pubmed-author:WeigertJohannaJ,
pubmed-author:WurmSylviaS
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
583
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3718-24
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pubmed:meshHeading |
pubmed-meshheading:19818774-Adiponectin,
pubmed-meshheading:19818774-Adult,
pubmed-meshheading:19818774-Aged,
pubmed-meshheading:19818774-Aged, 80 and over,
pubmed-meshheading:19818774-Aminoimidazole Carboxamide,
pubmed-meshheading:19818774-Body Mass Index,
pubmed-meshheading:19818774-Cells, Cultured,
pubmed-meshheading:19818774-Cholesterol,
pubmed-meshheading:19818774-Diabetes Mellitus, Type 2,
pubmed-meshheading:19818774-Dose-Response Relationship, Drug,
pubmed-meshheading:19818774-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19818774-Galectin 3,
pubmed-meshheading:19818774-Humans,
pubmed-meshheading:19818774-Immunoblotting,
pubmed-meshheading:19818774-Male,
pubmed-meshheading:19818774-Metformin,
pubmed-meshheading:19818774-Middle Aged,
pubmed-meshheading:19818774-Monocytes,
pubmed-meshheading:19818774-Oleic Acid,
pubmed-meshheading:19818774-Palmitic Acid,
pubmed-meshheading:19818774-Pyrazoles,
pubmed-meshheading:19818774-Pyrimidines,
pubmed-meshheading:19818774-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19818774-Ribonucleotides,
pubmed-meshheading:19818774-Solubility,
pubmed-meshheading:19818774-Time Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes.
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pubmed:affiliation |
Department of Internal Medicine I, Regensburg University Hospital, D-93042 Regensburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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