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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-2-1
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pubmed:abstractText |
Early-life stress may affect 5-HT(1A) receptor circuitry, which could result in increased anxiety in later life. An increased anxiety phenotype in 5-HT(1A) receptor KO mice (1AKO) mice has been ascribed to 5-HT(1A) receptor absence during the early postnatal period. Thus, subtle and transient serotonergic changes during the early postnatal period may lead to an increased risk for developing stress-related disorders during adulthood.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Anxiety Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzodiazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Diazepam,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA-A,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/WAY 100635
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1873-2402
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pubmed:author |
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pubmed:copyrightInfo |
2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
309-16
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pubmed:meshHeading |
pubmed-meshheading:19811773-Age Factors,
pubmed-meshheading:19811773-Animals,
pubmed-meshheading:19811773-Animals, Newborn,
pubmed-meshheading:19811773-Anti-Anxiety Agents,
pubmed-meshheading:19811773-Anxiety,
pubmed-meshheading:19811773-Benzodiazepines,
pubmed-meshheading:19811773-Diazepam,
pubmed-meshheading:19811773-Disease Models, Animal,
pubmed-meshheading:19811773-Dose-Response Relationship, Drug,
pubmed-meshheading:19811773-Drug Interactions,
pubmed-meshheading:19811773-Exploratory Behavior,
pubmed-meshheading:19811773-Gene Expression Regulation, Developmental,
pubmed-meshheading:19811773-Hippocampus,
pubmed-meshheading:19811773-Maze Learning,
pubmed-meshheading:19811773-Mice,
pubmed-meshheading:19811773-Mice, Knockout,
pubmed-meshheading:19811773-Piperazines,
pubmed-meshheading:19811773-Prefrontal Cortex,
pubmed-meshheading:19811773-Pyridines,
pubmed-meshheading:19811773-RNA, Messenger,
pubmed-meshheading:19811773-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:19811773-Receptors, GABA-A,
pubmed-meshheading:19811773-Serotonin Antagonists,
pubmed-meshheading:19811773-Vocalization, Animal
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pubmed:year |
2010
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pubmed:articleTitle |
Early-life blockade of 5-HT(1A) receptors alters adult anxiety behavior and benzodiazepine sensitivity.
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pubmed:affiliation |
Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neurosciences, Utrecht University, The Netherlands. c.h.vinkers@uu.nl
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pubmed:publicationType |
Journal Article
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