rdf:type |
|
lifeskim:mentions |
umls-concept:C0003009,
umls-concept:C0018801,
umls-concept:C0035820,
umls-concept:C0040649,
umls-concept:C0079281,
umls-concept:C0175630,
umls-concept:C0521451,
umls-concept:C0542341,
umls-concept:C1521761,
umls-concept:C1707310,
umls-concept:C2587213
|
pubmed:issue |
4
|
pubmed:dateCreated |
2009-10-7
|
pubmed:abstractText |
Evidence is emerging to support the concept that the failing heart is "energy depleted" and that defects in energy metabolism are important determinants in the development and the progression of the disease. We have shown previously that depressed mitochondrial function in cardiac and skeletal muscles in chronic heart failure is linked to decreased expression of the gene encoding transcriptional proliferator-activated receptor-gamma coactivator-1alpha, the inducible regulator of mitochondrial biogenesis and its transcription cascade, leading to altered expression of mitochondrial proteins. However, oxidative capacity of the myocardium of patients treated for chronic heart failure and pathophysiological mechanisms of mitochondrial dysfunction are still largely unknown.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
1941-3297
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
2
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
342-50
|
pubmed:meshHeading |
pubmed-meshheading:19808358-Angiotensin II,
pubmed-meshheading:19808358-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:19808358-Animals,
pubmed-meshheading:19808358-Down-Regulation,
pubmed-meshheading:19808358-Endothelin-1,
pubmed-meshheading:19808358-Female,
pubmed-meshheading:19808358-Heart Failure,
pubmed-meshheading:19808358-Heat-Shock Proteins,
pubmed-meshheading:19808358-Humans,
pubmed-meshheading:19808358-Male,
pubmed-meshheading:19808358-Middle Aged,
pubmed-meshheading:19808358-Mitochondria, Heart,
pubmed-meshheading:19808358-Oxygen Consumption,
pubmed-meshheading:19808358-Rats,
pubmed-meshheading:19808358-Transcription Factors
|
pubmed:year |
2009
|
pubmed:articleTitle |
Control by circulating factors of mitochondrial function and transcription cascade in heart failure: a role for endothelin-1 and angiotensin II.
|
pubmed:affiliation |
INSERM, U-769, Châtenay-Malabry, France. anne.garnier@u-psud.fr
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|