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rdf:type |
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lifeskim:mentions |
umls-concept:C0020792,
umls-concept:C0054871,
umls-concept:C0182400,
umls-concept:C0205099,
umls-concept:C0596545,
umls-concept:C0699919,
umls-concept:C1328819,
umls-concept:C1521991,
umls-concept:C1880022,
umls-concept:C1880355,
umls-concept:C2698650,
umls-concept:C2717970
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pubmed:issue |
13
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pubmed:dateCreated |
2009-11-20
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pubmed:abstractText |
During the pilot phase of the NIH Molecular Library Screening Network, the Penn Center for Molecular Discovery focused on a series of projects aimed at high throughput screening and the development of probes of a variety of protease targets. This review provides our medicinal chemistry experience with two such targets--cathepsin B and cathepsin L. We describe our approach for hit validation, characterization and triage that led to a critical understanding of the nature of hits from the cathepsin B project. In addition, we detail our experience at hit identification and optimization that led to the development of a novel thiocarbazate probe of cathepsin L.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-10353643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-10410800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-10479298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-10600517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-11259830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-11733355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-11888206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-12133721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-12678829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-12844438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-1447732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-15012988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-15542455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-15631471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-15831716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-16081529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-16408018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-16918357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-16925519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-17447748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-17579124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-17656088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-17928356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-18181690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-18184658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-18333608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-18363325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19807666-18499453
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1873-4294
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1206-16
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
The identification, characterization and optimization of small molecule probes of cysteine proteases: experiences of the Penn Center for Molecular Discovery with cathepsin B and cathepsin L.
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pubmed:affiliation |
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA. Huryn@sas.upenn.edu
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pubmed:publicationType |
Journal Article,
Review,
Research Support, N.I.H., Extramural
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