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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2009-10-12
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pubmed:abstractText |
The profile of a series of triazine and pyrimidine based ROCK inhibitors is described. An initial binding mode was established based on a homology model and the proposed interactions are consistent with the observed SAR. Compounds from the series are potent in a cell migration assay and possess a favorable kinase selectivity. In vivo activity was demonstrated for compound 1A in a spontaneous hypertensive rat model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BeasleyJames RJR,
pubmed-author:BelangerLauraL,
pubmed-author:BlackDarceyD,
pubmed-author:ChanJui-HsiangJH,
pubmed-author:DunnDavidD,
pubmed-author:HoKoc-KanKK,
pubmed-author:HuBingB,
pubmed-author:KlonAnthonyA,
pubmed-author:KlosIu SIuS,
pubmed-author:KultgenSteven GSG,
pubmed-author:MoeMM,
pubmed-author:OhlmeyerMichaelM,
pubmed-author:ParlatoSusan MSM,
pubmed-author:PhamQuynhchiQ,
pubmed-author:RayPeter CPC,
pubmed-author:RongYajingY,
pubmed-author:RoughtonAndrew LAL,
pubmed-author:WalkerTiffany LTL,
pubmed-author:WebbMariaM,
pubmed-author:WrightJaneJ,
pubmed-author:ZhangLimeiL
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6027-31
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pubmed:meshHeading |
pubmed-meshheading:19800787-Animals,
pubmed-meshheading:19800787-Antihypertensive Agents,
pubmed-meshheading:19800787-Binding Sites,
pubmed-meshheading:19800787-Computer Simulation,
pubmed-meshheading:19800787-Disease Models, Animal,
pubmed-meshheading:19800787-Hypertension,
pubmed-meshheading:19800787-Protein Kinase Inhibitors,
pubmed-meshheading:19800787-Pyrimidines,
pubmed-meshheading:19800787-Rats,
pubmed-meshheading:19800787-Structure-Activity Relationship,
pubmed-meshheading:19800787-Triazines,
pubmed-meshheading:19800787-rho-Associated Kinases
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pubmed:year |
2009
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pubmed:articleTitle |
Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model.
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pubmed:affiliation |
Ligand Pharmaceuticals, Inc., 3000 Eastpark Boulevard, Cranbury, NJ 08512, USA. kho@ligand.com
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pubmed:publicationType |
Journal Article
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