| pubmed-article:1978325 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1978325 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:1978325 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:1978325 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:1978325 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1978325 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:1978325 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:1978325 | pubmed:dateCreated | 1990-12-7 | lld:pubmed |
| pubmed-article:1978325 | pubmed:abstractText | The region-specific patterns of expression of mouse homeobox genes are considered important for establishing the embryonic body plan. A 5-kilobase (kb) DNA fragment from the Hox-3.1 locus that is sufficient to confer region-specific expression to a beta-galactosidase reporter gene in transgenic mouse embryos has been defined. The observed reporter gene expression pattern closely parallels endogenous Hox-3.1 expression in 8- to 9.5-day postcoitum (p.c.) embryos. At 10.5 days p.c. and later, the pattern of beta-galactosidase activity diverges from the Hox-3.1 pattern, and an inappropriately high level of reporter gene expression is observed in posterior spinal ganglia. Inclusion of an additional 2 kb of upstream sequences is sufficient to suppress this aberrant expression in the developing spinal ganglia. Together, these results show that the control of early Hox-3.1 expression is complex, involving at least one positively acting and one negatively acting element. | lld:pubmed |
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| pubmed-article:1978325 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1978325 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1978325 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1978325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1978325 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1978325 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1978325 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1978325 | pubmed:author | pubmed-author:RuddleF HFH | lld:pubmed |
| pubmed-article:1978325 | pubmed:author | pubmed-author:AwgulewitschA... | lld:pubmed |
| pubmed-article:1978325 | pubmed:author | pubmed-author:BieberichC... | lld:pubmed |
| pubmed-article:1978325 | pubmed:author | pubmed-author:UtsetM FMF | lld:pubmed |
| pubmed-article:1978325 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1978325 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:1978325 | pubmed:geneSymbol | lacZ | lld:pubmed |
| pubmed-article:1978325 | pubmed:geneSymbol | Hox-3.1 | lld:pubmed |
| pubmed-article:1978325 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1978325 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1978325 | pubmed:pagination | 8462-6 | lld:pubmed |
| pubmed-article:1978325 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1978325 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1978325 | pubmed:articleTitle | Evidence for positive and negative regulation of the Hox-3.1 gene. | lld:pubmed |
| pubmed-article:1978325 | pubmed:affiliation | Department of Biology, Yale University, New Haven, CT 06511. | lld:pubmed |
| pubmed-article:1978325 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1978325 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1978325 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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