| pubmed-article:19778377 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19778377 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:19778377 | lifeskim:mentions | umls-concept:C0001271 | lld:lifeskim |
| pubmed-article:19778377 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:19778377 | lifeskim:mentions | umls-concept:C1156237 | lld:lifeskim |
| pubmed-article:19778377 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:19778377 | pubmed:issue | 8A | lld:pubmed |
| pubmed-article:19778377 | pubmed:dateCreated | 2009-9-25 | lld:pubmed |
| pubmed-article:19778377 | pubmed:abstractText | Mitogenic regulation by caveolin-2 in response to insulin was investigated. Insulin triggered phosphorylation of caveolin-2 on tyrosine 19. Insulin increased the interaction between pY19-caveolin-2 and phospho-ERK, and that interaction was inhibited by a MEK inhibitor U0126. Insulin-induced interaction of caveolin-2 with phospho-ERK was prevented when tyrosine 19 is mutated to alanine. Insulin relocalized phospho-ERK and pY19-caveolin-2 to the nucleus and their nuclear co-localization was impaired by U0126. Down-regulation of caveolin-2 by caveolin-2 siRNA arrested the insulin-induced nuclear localization of ERK with no change in the insulin-stimulated ERK activation. Of consequence, the caveolin-2 siRNA attenuated the ERK-mediated c-Jun and cyclinD1 expression and DNA synthesis by insulin. In addition, actin cytoskeleton influenced the nuclear translocation of caveolin-2-ERK complex. Collectively, our findings underscore the importance of pY19-caveolin-2 with the spatial coordination by insulin in ERK-mediated mitogenic regulation of insulin signalling and indicate that the phosphorylation of pY19-caveolin-2 is required for actin cytoskeleton-dependent ERK nuclear import. | lld:pubmed |
| pubmed-article:19778377 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19778377 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19778377 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19778377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19778377 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19778377 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19778377 | pubmed:issn | 1582-4934 | lld:pubmed |
| pubmed-article:19778377 | pubmed:author | pubmed-author:PakYunbaeY | lld:pubmed |
| pubmed-article:19778377 | pubmed:author | pubmed-author:JeongKyuhoK | lld:pubmed |
| pubmed-article:19778377 | pubmed:author | pubmed-author:KwonHayeongH | lld:pubmed |
| pubmed-article:19778377 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19778377 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:19778377 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19778377 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19778377 | pubmed:pagination | 1549-64 | lld:pubmed |
| pubmed-article:19778377 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:19778377 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19778377 | pubmed:articleTitle | Identification of pY19-caveolin-2 as a positive regulator of insulin-stimulated actin cytoskeleton-dependent mitogenesis. | lld:pubmed |
| pubmed-article:19778377 | pubmed:affiliation | Department of Biochemistry, Division of Applied Life Science (BK21), Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju, Korea. | lld:pubmed |
| pubmed-article:19778377 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19778377 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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