19778024

Source:http://linkedlifedata.com/resource/pubmed/id/19778024

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0031727, umls-concept:C0040877, umls-concept:C0140079, umls-concept:C0205210, umls-concept:C1527148, umls-concept:C1880355, umls-concept:C1999216, umls-concept:C2346450
pubmed:issue	23
pubmed:dateCreated	2009-12-3
pubmed:abstractText	This report describes the biological activity, characterization, and SAR leading to 9d (BMS-754807) a small molecule IGF-1R kinase inhibitor in clinical development.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9716531
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 1, http://linkedlifedata.com/resource/pubmed/chemical/Triazines
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	1520-4804
pubmed:author	pubmed-author:AntmanMelissaM, pubmed-author:AttarRicardoR, pubmed-author:BalimanePraveenP, pubmed-author:CarboniJoan MJM, pubmed-author:ChangChiehyingC, pubmed-author:ChenCliffC, pubmed-author:DiscenzaLorellL, pubmed-author:EngGraceG, pubmed-author:FrennessonDavidD, pubmed-author:GottardisMarco MMM, pubmed-author:HurlburtWarrenW, pubmed-author:JohnsonWalterW, pubmed-author:LangleyDavid RDR, pubmed-author:LeeFrancis YFY, pubmed-author:LiAixinA, pubmed-author:LiJianqingJ, pubmed-author:LiuPeiyingP, pubmed-author:MastalerzHaroldH, pubmed-author:MathurArvindA, pubmed-author:MenardKristaK, pubmed-author:PatelKarishmaK, pubmed-author:SackJohnJ, pubmed-author:SangXiaopengX, pubmed-author:SaulnierMarkM, pubmed-author:SmithDanielD, pubmed-author:StefanskiKevinK, pubmed-author:TrainorGeorgeG, pubmed-author:VelaparthiUpenderU, pubmed-author:VyasDolatrai MDM, pubmed-author:WittmanMark DMD, pubmed-author:YangZhengZ, pubmed-author:ZhangGuifenG, pubmed-author:ZimmermannKurtK
pubmed:issnType	Electronic
pubmed:day	10
pubmed:volume	52
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	7360-3
pubmed:meshHeading	pubmed-meshheading:19778024-Animals, pubmed-meshheading:19778024-Biomedical Research, pubmed-meshheading:19778024-Dogs, pubmed-meshheading:19778024-Drug Discovery, pubmed-meshheading:19778024-Humans, pubmed-meshheading:19778024-Mice, pubmed-meshheading:19778024-Models, Molecular, pubmed-meshheading:19778024-Molecular Conformation, pubmed-meshheading:19778024-Protein Kinase Inhibitors, pubmed-meshheading:19778024-Pyrazoles, pubmed-meshheading:19778024-Rats, pubmed-meshheading:19778024-Receptor, IGF Type 1, pubmed-meshheading:19778024-Structure-Activity Relationship, pubmed-meshheading:19778024-Triazines
pubmed:year	2009
pubmed:articleTitle	Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.
pubmed:affiliation	Bristol-Myers Squibb Co, Wallingford, Connecticut 06492, USA.
pubmed:publicationType	Journal Article