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rdf:type |
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lifeskim:mentions |
umls-concept:C0014239,
umls-concept:C0018787,
umls-concept:C0031164,
umls-concept:C0038435,
umls-concept:C0301625,
umls-concept:C0521451,
umls-concept:C0684336,
umls-concept:C1522564,
umls-concept:C1545588,
umls-concept:C1705165,
umls-concept:C2700061
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pubmed:issue |
12
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pubmed:dateCreated |
2009-11-26
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pubmed:abstractText |
Alteration in endoplasmic reticulum (ER) stress in diabetic hearts and its effect on cytoprotective signaling are unclear. Here, we examine the hypothesis that ER stress in diabetic hearts impairs phospho-glycogen synthase kinase (GSK)-3beta-mediated suppression of mitochondrial permeability transition pore (mPTP) opening, compromising myocardial response to cytoprotective signaling.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2863-72
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:19755525-Animals,
pubmed-meshheading:19755525-Blood Glucose,
pubmed-meshheading:19755525-Body Weight,
pubmed-meshheading:19755525-Calcium,
pubmed-meshheading:19755525-Diabetes Mellitus, Type 2,
pubmed-meshheading:19755525-Endoplasmic Reticulum,
pubmed-meshheading:19755525-Erythropoietin,
pubmed-meshheading:19755525-Glycogen Synthase Kinase 3,
pubmed-meshheading:19755525-Immunoblotting,
pubmed-meshheading:19755525-Intracellular Membranes,
pubmed-meshheading:19755525-Male,
pubmed-meshheading:19755525-Membrane Potential, Mitochondrial,
pubmed-meshheading:19755525-Mitochondria, Heart,
pubmed-meshheading:19755525-Myocardial Infarction,
pubmed-meshheading:19755525-Myocardial Reperfusion,
pubmed-meshheading:19755525-Myocardium,
pubmed-meshheading:19755525-Myocytes, Cardiac,
pubmed-meshheading:19755525-Permeability,
pubmed-meshheading:19755525-Phosphorylation,
pubmed-meshheading:19755525-Rats,
pubmed-meshheading:19755525-Rats, Inbred OLETF,
pubmed-meshheading:19755525-Taurochenodeoxycholic Acid
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pubmed:year |
2009
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pubmed:articleTitle |
Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition.
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pubmed:affiliation |
Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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