| pubmed-article:19745158 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19745158 | lifeskim:mentions | umls-concept:C0025933 | lld:lifeskim |
| pubmed-article:19745158 | lifeskim:mentions | umls-concept:C0384648 | lld:lifeskim |
| pubmed-article:19745158 | lifeskim:mentions | umls-concept:C0031154 | lld:lifeskim |
| pubmed-article:19745158 | lifeskim:mentions | umls-concept:C1825592 | lld:lifeskim |
| pubmed-article:19745158 | lifeskim:mentions | umls-concept:C1705947 | lld:lifeskim |
| pubmed-article:19745158 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:19745158 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:19745158 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19745158 | pubmed:dateCreated | 2010-1-5 | lld:pubmed |
| pubmed-article:19745158 | pubmed:abstractText | IL-17A is a proinflammatory cytokine critical for host defense and involved in the pathogenesis of autoimmune disorders. Obesity is associated with chronic low-grade inflammation but also with a heightened acute inflammatory response. We investigated the effect of obesity on IL-17A production using the model of ZY-induced peritonitis. Compared with lean controls, administration of ZY induced a significantly exacerbated inflammatory response in obese leptin-deficient ob/ob mice and in mice with diet-induced obesity (DIO). Levels of IL-17A in the peritoneal fluid in response to ZY were elevated significantly in ob/ob and DIO mice compared with lean animals. Reconstitution of ob/ob mice with exogenous leptin did not alter production of IL-17A significantly in response to ZY. Peritoneal cells and adipose tissue obtained from ZY-injected obese mice expressed significantly higher levels of IL-17A mRNA compared with lean mice. Approximately 2% of peritoneal Ly6G(+) neutrophils from ZY-injected obese mice expressed IL-17A protein, compared with 0.2% of cells obtained from lean mice. Neutralization of IL-17 in ob/ob mice inhibited neutrophil recruitment and production of neutrophil-attracting CXC chemokines and IL-6, without affecting macrophage infiltration or levels of IL-10 and the chemokine CCL2. In contrast, neutralization of IL-6 did not affect production of IL-17A or chemokines while reducing production of the acute-phase protein serum amyloid A significantly. These data demonstrate that neutrophil-derived IL-17A is increased in obese mice during acute inflammation and contributes to exacerbation of inflammatory responses. | lld:pubmed |
| pubmed-article:19745158 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19745158 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19745158 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19745158 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19745158 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19745158 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19745158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19745158 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19745158 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19745158 | pubmed:issn | 1938-3673 | lld:pubmed |
| pubmed-article:19745158 | pubmed:author | pubmed-author:FantuzziGiami... | lld:pubmed |
| pubmed-article:19745158 | pubmed:author | pubmed-author:PiniMariaM | lld:pubmed |
| pubmed-article:19745158 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19745158 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:19745158 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19745158 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19745158 | pubmed:pagination | 51-8 | lld:pubmed |
| pubmed-article:19745158 | pubmed:dateRevised | 2010-3-11 | lld:pubmed |
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| pubmed-article:19745158 | pubmed:meshHeading | pubmed-meshheading:19745158... | lld:pubmed |
| pubmed-article:19745158 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19745158 | pubmed:articleTitle | Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice. | lld:pubmed |
| pubmed-article:19745158 | pubmed:affiliation | Department of Kinesiology, University of Illinois, Chicago, IL 60612, USA. | lld:pubmed |
| pubmed-article:19745158 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19745158 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:19745158 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:16171 | entrezgene:pubmed | pubmed-article:19745158 | lld:entrezgene |
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