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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-9-23
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pubmed:abstractText |
Selective binding of multivalent ligands within a mixture of polyvalent amphiphiles provides, in principle, a simple mechanism for driving domain formation in self-assemblies. Divalent cations are shown here to crossbridge polyanionic amphiphiles, which thereby demix from neutral amphiphiles and form spots or rafts within vesicles as well as stripes within cylindrical micelles. Calcium- and copper-crossbridged domains of synthetic block copolymers or natural lipid (phosphatidylinositol-4,5-bisphosphate) possess tunable sizes, shapes and/or spacings that can last for years. Lateral segregation in these 'ligand-responsive Janus assemblies' couples weakly to curvature and proves to be restricted within phase diagrams to narrow regimes of pH and cation concentration that are centred near the characteristic binding constants for polyacid interactions. Remixing at high pH is surprising, but a theory for strong lateral segregation shows that counterion entropy dominates electrostatic crossbridges, thus illustrating the insights gained into ligand-induced pattern formation within self-assemblies.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-10411897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-11749172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-12169723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-14527454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-14574408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-14581208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-15459386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-15459387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-15658783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-15807557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-16319880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-16851424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-17667968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-17673656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-17673657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-18083096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-18189443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-18763779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-19206328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-19773784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19734886-3474616
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1476-1122
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
843-9
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pubmed:dateRevised |
2011-5-2
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding.
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pubmed:affiliation |
Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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