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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-6-17
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pubmed:abstractText |
Considering the chronic and repeated nature of salmon calcitonin (sCT) therapy, the oral route is a preferred route of administration. But, the oral bioavailability of sCT is very low due to enzymatic degradation and poor permeation across intestinal epithelial cells. It was the aim of this study to investigate the pharmacodynamic (PD), pharmacokinetic (PK), and mucosal injury characteristic of sCT oral delivery system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1520-5762
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pubmed:author |
pubmed-author:ChenXijingX,
pubmed-author:GaoZidongZ,
pubmed-author:HanDeenD,
pubmed-author:LiTingtingT,
pubmed-author:N,
pubmed-author:ObiII,
pubmed-author:SunQianQ,
pubmed-author:SunWeiW,
pubmed-author:SunYaY,
pubmed-author:WangLeiL,
pubmed-author:WangMulanM,
pubmed-author:WuLeiL,
pubmed-author:WuYaningY,
pubmed-author:XueYuY,
pubmed-author:ZANARR,
pubmed-author:ZhangGeG,
pubmed-author:ZhaoDiD
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pubmed:issnType |
Electronic
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
362-70
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pubmed:meshHeading |
pubmed-meshheading:19719396-Animals,
pubmed-meshheading:19719396-Bone Density Conservation Agents,
pubmed-meshheading:19719396-Calcitonin,
pubmed-meshheading:19719396-Calcium,
pubmed-meshheading:19719396-Capsules,
pubmed-meshheading:19719396-Chemistry, Pharmaceutical,
pubmed-meshheading:19719396-Citric Acid,
pubmed-meshheading:19719396-Delayed-Action Preparations,
pubmed-meshheading:19719396-Drug Administration Routes,
pubmed-meshheading:19719396-Drug Delivery Systems,
pubmed-meshheading:19719396-Female,
pubmed-meshheading:19719396-Gastric Mucosa,
pubmed-meshheading:19719396-Gastrointestinal Diseases,
pubmed-meshheading:19719396-Half-Life,
pubmed-meshheading:19719396-Intestinal Absorption,
pubmed-meshheading:19719396-Intestinal Mucosa,
pubmed-meshheading:19719396-Rats,
pubmed-meshheading:19719396-Rats, Sprague-Dawley,
pubmed-meshheading:19719396-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Evaluation of salmon calcitonin (sCT) enteric-coated capsule for enhanced absorption and GI tolerability in rats.
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pubmed:affiliation |
Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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