Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8682
|
| pubmed:dateCreated |
1990-2-16
|
| pubmed:abstractText |
A female patient showed rejection of a T-lymphocyte-depleted bone-marrow graft from her phenotypically HLA-identical father. Before bone-marrow transplantation, there was strong recipient anti-donor cellular cytotoxic reactivity directed against several minor histocompatibility (mH) antigens, including the male-specific H-Y antigen. After conditioning treatment, no recipient anti-donor cytotoxic activity could be detected, and good graft function was shown a month after transplantation. Thereafter, however, graft function deteriorated rapidly, while recipient-derived anti-donor cellular cytotoxic reactivity, against similar mH antigens, reappeared. The recipient-derived cytotoxic T lymphocytes could completely inhibit growth of donor haemopoietic progenitor cells both before and after bone-marrow transplantation. Thus, cytotoxic T lymphocytes can survive very intensive conditioning regimens, and residual recipient cytotoxic T lymphocytes directed against mH antigens expressed on donor haemopoietic progenitor cells may cause graft rejection after HLA-identical T-lymphocyte-depleted bone-marrow transplantation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
335
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
131-4
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1967432-Adult,
pubmed-meshheading:1967432-Bone Marrow Transplantation,
pubmed-meshheading:1967432-Cell Line,
pubmed-meshheading:1967432-Chromosome Mapping,
pubmed-meshheading:1967432-Evaluation Studies as Topic,
pubmed-meshheading:1967432-Female,
pubmed-meshheading:1967432-Graft Rejection,
pubmed-meshheading:1967432-H-Y Antigen,
pubmed-meshheading:1967432-HLA Antigens,
pubmed-meshheading:1967432-Hematopoietic Stem Cells,
pubmed-meshheading:1967432-Humans,
pubmed-meshheading:1967432-Lymphocyte Depletion,
pubmed-meshheading:1967432-Male,
pubmed-meshheading:1967432-Metaphase,
pubmed-meshheading:1967432-Myelodysplastic Syndromes,
pubmed-meshheading:1967432-Phenotype,
pubmed-meshheading:1967432-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:1967432-Time Factors,
pubmed-meshheading:1967432-Transplantation Immunology
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Rejection of bone-marrow graft by recipient-derived cytotoxic T lymphocytes against minor histocompatibility antigens.
|
| pubmed:affiliation |
Department of Haematology, University Hospital, Leiden, Netherlands.
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|