| pubmed-article:19661922 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19661922 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:19661922 | lifeskim:mentions | umls-concept:C0299247 | lld:lifeskim |
| pubmed-article:19661922 | lifeskim:mentions | umls-concept:C1333699 | lld:lifeskim |
| pubmed-article:19661922 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19661922 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19661922 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:19661922 | pubmed:dateCreated | 2009-9-17 | lld:pubmed |
| pubmed-article:19661922 | pubmed:abstractText | G protein-coupled receptors (GPCRs) have been found to trigger G protein-independent signalling. However, the regulation of G protein-independent pathways, especially their desensitization, is poorly characterized. Here, we show that the G protein-independent 5-HT(4) receptor (5-HT(4)R)-operated Src/ERK (extracellular signal-regulated kinase) pathway, but not the G(s) pathway, is inhibited by GPCR kinase 5 (GRK5), physically associated with the proximal region of receptor' C-terminus in both human embryonic kidney (HEK)-293 cells and colliculi neurons. This inhibition required two sequences of events: the association of beta-arrestin1 to a phosphorylated serine/threonine cluster located within the receptor C-t domain and the phosphorylation, by GRK5, of beta-arrestin1 (at Ser(412)) bound to the receptor. Phosphorylated beta-arrestin1 in turn prevented activation of Src constitutively bound to 5-HT(4)Rs, a necessary step in receptor-stimulated ERK signalling. This is the first demonstration that beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent signalling. | lld:pubmed |
| pubmed-article:19661922 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19661922 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661922 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19661922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661922 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19661922 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19661922 | pubmed:issn | 1460-2075 | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:BenovicJeffre... | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:DumuisAlineA | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:ReiterEricE | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:BockaertJoëlJ | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:ClaeysenSylvi... | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:MarinPhilippe... | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:KangDong... | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:GavenFlorence... | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:BanèresJean-L... | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:BarthetGaëlG | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:FrameryBéréni... | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:AugierJulieJ | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:PellissierLuc... | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:PillotMarionM | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:CarratGaëlleG | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:CassierElizab... | lld:pubmed |
| pubmed-article:19661922 | pubmed:author | pubmed-author:BarkerBreannB | lld:pubmed |
| pubmed-article:19661922 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19661922 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:19661922 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:19661922 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19661922 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19661922 | pubmed:pagination | 2706-18 | lld:pubmed |
| pubmed-article:19661922 | pubmed:dateRevised | 2010-9-17 | lld:pubmed |
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| pubmed-article:19661922 | pubmed:meshHeading | pubmed-meshheading:19661922... | lld:pubmed |
| pubmed-article:19661922 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19661922 | pubmed:articleTitle | Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. | lld:pubmed |
| pubmed-article:19661922 | pubmed:affiliation | Institut de Génomique Fonctionnelle, Universités de Montpellier, CNRS, Montpellier, France. | lld:pubmed |
| pubmed-article:19661922 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19661922 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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