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| pubmed-article:19642983 | lifeskim:mentions | umls-concept:C0345904 | lld:lifeskim |
| pubmed-article:19642983 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:19642983 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:19642983 | lifeskim:mentions | umls-concept:C0005304 | lld:lifeskim |
| pubmed-article:19642983 | lifeskim:mentions | umls-concept:C0525037 | lld:lifeskim |
| pubmed-article:19642983 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19642983 | lifeskim:mentions | umls-concept:C1516211 | lld:lifeskim |
| pubmed-article:19642983 | lifeskim:mentions | umls-concept:C0376452 | lld:lifeskim |
| pubmed-article:19642983 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:19642983 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19642983 | pubmed:dateCreated | 2009-8-28 | lld:pubmed |
| pubmed-article:19642983 | pubmed:abstractText | The development and progression of liver cancer may involve abnormal changes in DNA methylation, which lead to the activation of certain proto-oncogenes, such as c-myc, as well as the inactivation of certain tumor suppressors, such as p16. Betaine, as an active methyl-donor, maintains normal DNA methylation patterns. However, there are few investigations on the protective effect of betaine in hepatocarcinogenesis. | lld:pubmed |
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| pubmed-article:19642983 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19642983 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19642983 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19642983 | pubmed:issn | 1471-2407 | lld:pubmed |
| pubmed-article:19642983 | pubmed:author | pubmed-author:PengJun-sheng... | lld:pubmed |
| pubmed-article:19642983 | pubmed:author | pubmed-author:TangZhi-hongZ... | lld:pubmed |
| pubmed-article:19642983 | pubmed:author | pubmed-author:DuYan-pingYP | lld:pubmed |
| pubmed-article:19642983 | pubmed:author | pubmed-author:LingWen-huaWH | lld:pubmed |
| pubmed-article:19642983 | pubmed:author | pubmed-author:ZhuHui-lianHL | lld:pubmed |
| pubmed-article:19642983 | pubmed:author | pubmed-author:SunAiA | lld:pubmed |
| pubmed-article:19642983 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19642983 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:19642983 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19642983 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19642983 | pubmed:pagination | 261 | lld:pubmed |
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| pubmed-article:19642983 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19642983 | pubmed:articleTitle | Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model. | lld:pubmed |
| pubmed-article:19642983 | pubmed:affiliation | School of public health, Sun Yat-Sen University, Guangzhou 510080, PR China. ypdu518@163.com | lld:pubmed |
| pubmed-article:19642983 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19642983 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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