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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1992-1-6
|
| pubmed:abstractText |
Chromosome in situ hybridization studies showed that the normal karyotype of leukemic cells from a patient with Ph1-negative, BCR-positive chronic myeloid leukemia (CML) concealed a complex t(9;22;20)(q34;q11;p13). The close association of 5'-BCR and 3'-ABL was demonstrated by field inversion gel electrophoresis, and in situ hybridization showed that BCR-ABL was located on the short arm of chromosome 20. Our findings further indicate that chromosome rearrangement is the cause of BCR-ABL gene fusion in leukemic cells that show a normal karyotype. Results from in situ hybridization studies were consistent with formation of the t(9;22;20) by a two step chromosomal rearrangement, but field inversion gel electrophoresis results indicated a more complex rearrangement.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1045-2257
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:geneSymbol |
ABL,
BCR
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
263-71
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1958592-Aged,
pubmed-meshheading:1958592-Chromosomes, Human, Pair 20,
pubmed-meshheading:1958592-Chromosomes, Human, Pair 22,
pubmed-meshheading:1958592-Chromosomes, Human, Pair 9,
pubmed-meshheading:1958592-DNA, Neoplasm,
pubmed-meshheading:1958592-Female,
pubmed-meshheading:1958592-Fusion Proteins, bcr-abl,
pubmed-meshheading:1958592-Gene Rearrangement,
pubmed-meshheading:1958592-Genes, abl,
pubmed-meshheading:1958592-Genetic Markers,
pubmed-meshheading:1958592-Humans,
pubmed-meshheading:1958592-Karyotyping,
pubmed-meshheading:1958592-Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative,
pubmed-meshheading:1958592-Nucleic Acid Hybridization,
pubmed-meshheading:1958592-Restriction Mapping,
pubmed-meshheading:1958592-Translocation, Genetic,
pubmed-meshheading:1958592-Tumor Markers, Biological
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
A complex chromosome rearrangement forms the BCR-ABL fusion gene in leukemic cells with a normal karyotype.
|
| pubmed:affiliation |
Cytogenetic and Molecular Oncology Unit, Christchurch School of Medicine, New Zealand.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports,
Research Support, Non-U.S. Gov't
|