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rdf:type |
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lifeskim:mentions |
umls-concept:C0007581,
umls-concept:C0013081,
umls-concept:C0014257,
umls-concept:C0021107,
umls-concept:C0055729,
umls-concept:C0072980,
umls-concept:C0205263,
umls-concept:C0302350,
umls-concept:C0541315,
umls-concept:C1322815,
umls-concept:C2720167
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pubmed:issue |
24
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pubmed:dateCreated |
2009-6-12
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pubmed:abstractText |
The aim of this study was to compare the effects of paclitaxel, sirolimus, and everolimus on the senescent phenotype in human endothelial cells, and to further investigate possible involvement of mammalian sirtuin 1 (Sirt1) down-regulation as a mechanism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aspirin,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/NOS3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel,
http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen Activator Inhibitor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/SIRT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/Sirtuin 1,
http://linkedlifedata.com/resource/pubmed/chemical/Sirtuins,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Ticlopidine,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/cilostazol,
http://linkedlifedata.com/resource/pubmed/chemical/clopidogrel,
http://linkedlifedata.com/resource/pubmed/chemical/everolimus
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1558-3597
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2298-305
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19520256-Aspirin,
pubmed-meshheading:19520256-Cell Aging,
pubmed-meshheading:19520256-Down-Regulation,
pubmed-meshheading:19520256-Drug-Eluting Stents,
pubmed-meshheading:19520256-Endothelium, Vascular,
pubmed-meshheading:19520256-Humans,
pubmed-meshheading:19520256-Immunosuppressive Agents,
pubmed-meshheading:19520256-Nitric Oxide Synthase Type III,
pubmed-meshheading:19520256-Oxidative Stress,
pubmed-meshheading:19520256-Paclitaxel,
pubmed-meshheading:19520256-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:19520256-Platelet Aggregation Inhibitors,
pubmed-meshheading:19520256-Sirolimus,
pubmed-meshheading:19520256-Sirtuin 1,
pubmed-meshheading:19520256-Sirtuins,
pubmed-meshheading:19520256-Tetrazoles,
pubmed-meshheading:19520256-Ticlopidine,
pubmed-meshheading:19520256-Vasodilator Agents
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pubmed:year |
2009
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pubmed:articleTitle |
Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation: therapeutic implication of cilostazol after drug-eluting stent implantation.
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pubmed:affiliation |
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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