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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-7-23
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pubmed:abstractText |
Paired homeobox 2 gene (PAX2) is a transcriptional regulator, aberrantly expressed in prostate cancer cells and its down-regulation promotes cell death in these cells. The molecular mechanisms of tumor progression by PAX2 over-expression are still unclear. However, it has been reported that angiotensin-II (A-II) induces cell growth in prostate cancer via A-II type 1 receptor (AT1R) and is mediated by the phosphorylation of mitogen activated protein kinase (MAPK) as well as signal transducer and activator of transcription 3 (STAT3).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 2 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Losartan,
http://linkedlifedata.com/resource/pubmed/chemical/PAX2 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/PAX2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 2
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1097-0045
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1334-42
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19517575-Angiotensin II,
pubmed-meshheading:19517575-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:19517575-Angiotensin II Type 2 Receptor Blockers,
pubmed-meshheading:19517575-Cell Line, Tumor,
pubmed-meshheading:19517575-Cell Proliferation,
pubmed-meshheading:19517575-Cell Survival,
pubmed-meshheading:19517575-Enzyme Inhibitors,
pubmed-meshheading:19517575-Humans,
pubmed-meshheading:19517575-Losartan,
pubmed-meshheading:19517575-Male,
pubmed-meshheading:19517575-PAX2 Transcription Factor,
pubmed-meshheading:19517575-Phosphorylation,
pubmed-meshheading:19517575-Prostate,
pubmed-meshheading:19517575-Prostatic Neoplasms,
pubmed-meshheading:19517575-RNA, Messenger,
pubmed-meshheading:19517575-Receptor, Angiotensin, Type 2,
pubmed-meshheading:19517575-Signal Transduction,
pubmed-meshheading:19517575-Up-Regulation
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pubmed:year |
2009
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pubmed:articleTitle |
Angiotensin II up-regulates PAX2 oncogene expression and activity in prostate cancer via the angiotensin II type I receptor.
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pubmed:affiliation |
Department of Pathology & Lab Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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