| pubmed-article:19481591 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19481591 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:19481591 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:19481591 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:19481591 | lifeskim:mentions | umls-concept:C0061300 | lld:lifeskim |
| pubmed-article:19481591 | lifeskim:mentions | umls-concept:C0673446 | lld:lifeskim |
| pubmed-article:19481591 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:19481591 | pubmed:dateCreated | 2009-8-31 | lld:pubmed |
| pubmed-article:19481591 | pubmed:abstractText | Two isochinoline alkaloids, glaucine and oxoglaucine were investigated for their suggested anti-inflammatory influence concerning nitric oxide and cytokine production. Mouse peritoneal macrophages were stimulated with different Toll-like receptor (TLR) ligands such as LPS for TLR4, zymosan for TLR2 and CpG for TLR9. The alkaloids inhibited TNF-alpha and IL-6 production induced by these ligands. In regard to IL-12 suppressive effect was registered in the case of CpG stimulation. Glaucine succeeded to enhance LPS and zymosan-induced IL-10 production. The reduction of pro-inflammatory cytokines and increase of anti-inflammatory IL-10 are indicative for their use in different acute and chronic inflammatory diseases. | lld:pubmed |
| pubmed-article:19481591 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19481591 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19481591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481591 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19481591 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19481591 | pubmed:issn | 1873-6971 | lld:pubmed |
| pubmed-article:19481591 | pubmed:author | pubmed-author:DimitrovaPety... | lld:pubmed |
| pubmed-article:19481591 | pubmed:author | pubmed-author:IvanovskaNina... | lld:pubmed |
| pubmed-article:19481591 | pubmed:author | pubmed-author:PhilipovStefa... | lld:pubmed |
| pubmed-article:19481591 | pubmed:author | pubmed-author:RemichkovaMim... | lld:pubmed |
| pubmed-article:19481591 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19481591 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:19481591 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19481591 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19481591 | pubmed:pagination | 411-4 | lld:pubmed |
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| pubmed-article:19481591 | pubmed:meshHeading | pubmed-meshheading:19481591... | lld:pubmed |
| pubmed-article:19481591 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19481591 | pubmed:articleTitle | Toll-like receptor-mediated anti-inflammatory action of glaucine and oxoglaucine. | lld:pubmed |
| pubmed-article:19481591 | pubmed:affiliation | Department of Immunology, The Stephan Angeloff Institute of Microbiology, 1113 Sofia, Bulgaria. | lld:pubmed |
| pubmed-article:19481591 | pubmed:publicationType | Journal Article | lld:pubmed |
